Cholic acid
Cholic acid is a lipid of Sterol Lipids (ST) class. Cholic acid is associated with abnormalities such as Cholestasis, Intrahepatic Cholestasis, Atherosclerosis, Diabetes and cholesterol gallstones. The involved functions are known as Homeostasis, Enterohepatic Circulation, Proliferation (morphologic abnormality), Process and Cell Proliferation. Cholic acid often locates in Hepatic, Cytoplasmic matrix, Membrane, Protoplasm and Tissue membrane. The associated genes with Cholic acid are CYP27A1 gene, ABCB11 gene, NR5A2 gene, SLC10A2 gene and SLC10A1 gene. The related lipids are ursocholic acid, Steroids, Cholestenes, Cholestanes and cholanic acid.
References related to abnormalities published in Am. J. Physiol. Gastrointest. Liver Physiol.
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 21719738 | Am. J. Physiol. Gastrointest. Liver Physiol. | 2011 | Soroka CJ et al. | OstĪ± depletion protects liver from oral bile acid load. |
| 16357057 | Am. J. Physiol. Gastrointest. Liver Physiol. | 2006 | Zollner G et al. | Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids. |
| 27151938 | Am. J. Physiol. Gastrointest. Liver Physiol. | 2016 | Sun L et al. | Bile acids promote diethylnitrosamine-induced hepatocellular carcinoma via increased inflammatory signaling. |