rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

References related to abnormalities published in Am. J. Physiol. Heart Circ. Physiol.


PMIDJournalPublished DateAuthorTitle
11179083Am. J. Physiol. Heart Circ. Physiol.2001Fryer RM et al.Essential activation of PKC-delta in opioid-initiated cardioprotection.
12063302Am. J. Physiol. Heart Circ. Physiol.2002Kudo M et al.Adenosine A(1) receptor mediates late preconditioning via activation of PKC-delta signaling pathway.
17513490Am. J. Physiol. Heart Circ. Physiol.2007Miura T et al.Delta-opioid receptor activation before ischemia reduces gap junction permeability in ischemic myocardium by PKC-epsilon-mediated phosphorylation of connexin 43.