20-HETE
20-hete is a lipid of Fatty Acyls (FA) class. 20-hete is associated with abnormalities such as Cyst, Kidney Diseases, Kidney Failure, Chronic, Cystic Kidney Diseases and Simple renal cyst. The involved functions are known as Phosphorylation, inhibitors, Hypertrophy, Epithelial Cell Proliferation and Anabolism. 20-hete often locates in Mouse Kidney, Microsomes, Tissue membrane, Body tissue and Cytoplasmic matrix. The associated genes with 20-HETE are CYP4F3 gene, PKHD1 gene, Transgenes, P4HTM gene and CYP2E1 gene. The related lipids are Promega, enterodiol, Fatty Acids, hexanoic acid and U 73343. The related experimental models are Mouse Model, Knock-out, Streptozotocin Diabetes, Transgenic Model and Rodent Model.
References related to lipids published in Am. J. Physiol. Heart Circ. Physiol.
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 11668070 | Am. J. Physiol. Heart Circ. Physiol. | 2001 | Zhao X et al. | The CYP450 hydroxylase pathway contributes to P2X receptor-mediated afferent arteriolar vasoconstriction. |
| 11009437 | Am. J. Physiol. Heart Circ. Physiol. | 2000 | Zhu D et al. | Hypoxic pulmonary vasoconstriction is modified by P-450 metabolites. |
| 10924088 | Am. J. Physiol. Heart Circ. Physiol. | 2000 | Maier KG et al. | Fluorescent HPLC assay for 20-HETE and other P-450 metabolites of arachidonic acid. |
| 10899074 | Am. J. Physiol. Heart Circ. Physiol. | 2000 | Sun CW et al. | Role of cGMP versus 20-HETE in the vasodilator response to nitric oxide in rat cerebral arteries. |
| 15130884 | Am. J. Physiol. Heart Circ. Physiol. | 2004 | Zhang F et al. | Transfection of CYP4A1 cDNA decreases diameter and increases responsiveness of gracilis muscle arterioles to constrictor stimuli. |
| 21257913 | Am. J. Physiol. Heart Circ. Physiol. | 2011 | Harder DR et al. | Pressure-induced myogenic tone and role of 20-HETE in mediating autoregulation of cerebral blood flow. |
| 19136601 | Am. J. Physiol. Heart Circ. Physiol. | 2009 | Dhanasekaran A et al. | 20-HETE increases survival and decreases apoptosis in pulmonary arteries and pulmonary artery endothelial cells. |
| 20675568 | Am. J. Physiol. Heart Circ. Physiol. | 2010 | Zeng Q et al. | 20-HETE increases NADPH oxidase-derived ROS production and stimulates the L-type Ca2+ channel via a PKC-dependent mechanism in cardiomyocytes. |
| 20852048 | Am. J. Physiol. Heart Circ. Physiol. | 2010 | Sahan-Firat S et al. | 2,3',4,5'-Tetramethoxystilbene prevents deoxycorticosterone-salt-induced hypertension: contribution of cytochrome P-450 1B1. |
| 15576442 | Am. J. Physiol. Heart Circ. Physiol. | 2005 | Wang J et al. | Effects of high-salt diet on CYP450-4A omega-hydroxylase expression and active tone in mesenteric resistance arteries. |
| 17114243 | Am. J. Physiol. Heart Circ. Physiol. | 2007 | Marvar PJ et al. | High dietary salt reduces the contribution of 20-HETE to arteriolar oxygen responsiveness in skeletal muscle. |
| 16782846 | Am. J. Physiol. Heart Circ. Physiol. | 2006 | Fang X et al. | 20-Hydroxyeicosatetraenoic acid is a potent dilator of mouse basilar artery: role of cyclooxygenase. |