20-HETE
20-hete is a lipid of Fatty Acyls (FA) class. 20-hete is associated with abnormalities such as Cyst, Kidney Diseases, Kidney Failure, Chronic, Cystic Kidney Diseases and Simple renal cyst. The involved functions are known as Phosphorylation, inhibitors, Hypertrophy, Epithelial Cell Proliferation and Anabolism. 20-hete often locates in Mouse Kidney, Microsomes, Tissue membrane, Body tissue and Cytoplasmic matrix. The associated genes with 20-HETE are CYP4F3 gene, PKHD1 gene, Transgenes, P4HTM gene and CYP2E1 gene. The related lipids are Promega, enterodiol, Fatty Acids, hexanoic acid and U 73343. The related experimental models are Mouse Model, Knock-out, Streptozotocin Diabetes, Transgenic Model and Rodent Model.
References related to abnormalities published in Am. J. Physiol. Regul. Integr. Comp. Physiol.
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 11792647 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | 2002 | Wang MH et al. | Renal 20-hydroxyeicosatetraenoic acid synthesis during pregnancy. |
| 12069931 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | 2002 | Alonso-Galicia M et al. | Role of 20-hydroxyeicosatetraenoic acid in the renal and vasoconstrictor actions of angiotensin II. |
| 12626366 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | 2003 | Skott O | Androgen-induced activation of 20-HETE production may contribute to gender differences in blood pressure regulation. |
| 12531784 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | 2003 | Nakagawa K et al. | Androgen-mediated induction of the kidney arachidonate hydroxylases is associated with the development of hypertension. |
| 11124159 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | 2001 | Wang MH et al. | CYP4A1 antisense oligonucleotide reduces mesenteric vascular reactivity and blood pressure in SHR. |
| 15191921 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | 2004 | Imig JD | 20-HETE or EETs: which arachidonic acid metabolite regulates proximal tubule transporters and contributes to pressure natriuresis? |
| 21411763 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | 2011 | Sporková A et al. | Role of cytochrome P-450 metabolites in the regulation of renal function and blood pressure in 2-kidney 1-clip hypertensive rats. |
| 21474427 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | 2011 | Yanes LL et al. | Postmenopausal hypertension: role of 20-HETE. |
| 19261918 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | 2009 | Cao S et al. | Endothelin rather than 20-HETE contributes to loss of pial arteriolar dilation during focal cerebral ischemia with and without polymeric hemoglobin transfusion. |
| 15031141 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | 2004 | Dos Santos EA et al. | Inhibition of the formation of EETs and 20-HETE with 1-aminobenzotriazole attenuates pressure natriuresis. |
| 17303679 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | 2007 | Yu M et al. | Effects of 20-HETE on Na+ transport and Na+ -K+ -ATPase activity in the thick ascending loop of Henle. |
| 16166205 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | 2006 | Takeuchi K et al. | Hemoglobin, NO, and 20-HETE interactions in mediating cerebral vasoconstriction following SAH. |
| 22442195 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | 2012 | Williams JM et al. | Role of 20-HETE in the antihypertensive effect of transfer of chromosome 5 from Brown Norway to Dahl salt-sensitive rats. |
| 23220478 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | 2013 | Lima R et al. | Roles played by 20-HETE, angiotensin II and endothelin in mediating the hypertension in aging female spontaneously hypertensive rats. |
| 25924878 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | 2015 | Garcia V et al. | Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertension. |
| 25540098 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | 2015 | Fan F et al. | Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat. |