trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

References related to abnormalities published in Am. J. Physiol. Renal Physiol.


PMIDJournalPublished DateAuthorTitle
19553350Am. J. Physiol. Renal Physiol.2009Noh H et al.Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury.
19640900Am. J. Physiol. Renal Physiol.2009Pang M et al.Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy.
19906951Am. J. Physiol. Renal Physiol.2010Marumo T et al.Histone deacetylase modulates the proinflammatory and -fibrotic changes in tubulointerstitial injury.