20-HETE
20-hete is a lipid of Fatty Acyls (FA) class. 20-hete is associated with abnormalities such as Cyst, Kidney Diseases, Kidney Failure, Chronic, Cystic Kidney Diseases and Simple renal cyst. The involved functions are known as Phosphorylation, inhibitors, Hypertrophy, Epithelial Cell Proliferation and Anabolism. 20-hete often locates in Mouse Kidney, Microsomes, Tissue membrane, Body tissue and Cytoplasmic matrix. The associated genes with 20-HETE are CYP4F3 gene, PKHD1 gene, Transgenes, P4HTM gene and CYP2E1 gene. The related lipids are Promega, enterodiol, Fatty Acids, hexanoic acid and U 73343. The related experimental models are Mouse Model, Knock-out, Streptozotocin Diabetes, Transgenic Model and Rodent Model.
References related to pathways published in Am. J. Physiol. Renal Physiol.
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 12167590 | Am. J. Physiol. Renal Physiol. | 2002 | Gu RM and Wang WH | Arachidonic acid inhibits K channels in basolateral membrane of the thick ascending limb. |
| 12419775 | Am. J. Physiol. Renal Physiol. | 2003 | Cheng MK et al. | Renal arterial 20-hydroxyeicosatetraenoic acid levels: regulation by cyclooxygenase. |
| 15265768 | Am. J. Physiol. Renal Physiol. | 2004 | Li D et al. | Dietary K intake regulates the response of apical K channels to adenosine in the thick ascending limb. |
| 15998843 | Am. J. Physiol. Renal Physiol. | 2005 | Huang H et al. | Renal 20-HETE inhibition attenuates changes in renal hemodynamics induced by L-NAME treatment in pregnant rats. |
| 16396943 | Am. J. Physiol. Renal Physiol. | 2006 | Roman RJ et al. | Characterization of blood pressure and renal function in chromosome 5 congenic strains of Dahl S rats. |
| 17507602 | Am. J. Physiol. Renal Physiol. | 2007 | Williams JM et al. | Role of endogenous CYP450 metabolites of arachidonic acid in maintaining the glomerular protein permeability barrier. |
| 18171997 | Am. J. Physiol. Renal Physiol. | 2008 | Nilakantan V et al. | 20-HETE-mediated cytotoxicity and apoptosis in ischemic kidney epithelial cells. |
| 18842817 | Am. J. Physiol. Renal Physiol. | 2008 | Williams JM et al. | Transfer of the CYP4A region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury. |
| 19570883 | Am. J. Physiol. Renal Physiol. | 2009 | Akbulut T et al. | 20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism. |
| 19675180 | Am. J. Physiol. Renal Physiol. | 2009 | Inoue K et al. | Endothelial-specific CYP4A2 overexpression leads to renal injury and hypertension via increased production of 20-HETE. |