Sphingosine 1-phosphate

Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.

References related to abnormalities published in Am. J. Physiol., Cell Physiol.

PMID	Journal	Published Date	Author	Title
11997251	Am. J. Physiol., Cell Physiol.	2002	Formigli L et al.	Sphingosine 1-phosphate induces Ca2+ transients and cytoskeletal rearrangement in C2C12 myoblastic cells.
21270296	Am. J. Physiol., Cell Physiol.	2011	Hopson KP et al.	S1P activates store-operated calcium entry via receptor- and non-receptor-mediated pathways in vascular smooth muscle cells.
21289286	Am. J. Physiol., Cell Physiol.	2011	Sumida GM and Stamer WD	S1P₂ receptor regulation of sphingosine-1-phosphate effects on conventional outflow physiology.
19474291	Am. J. Physiol., Cell Physiol.	2009	Chang CL et al.	S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.
20042733	Am. J. Physiol., Cell Physiol.	2010	Danieli-Betto D et al.	Sphingosine 1-phosphate signaling is involved in skeletal muscle regeneration.
17942639	Am. J. Physiol., Cell Physiol.	2008	Zanin M et al.	Trophic action of sphingosine 1-phosphate in denervated rat soleus muscle.
17670896	Am. J. Physiol., Cell Physiol.	2007	Xu M et al.	Sphingosine 1-phosphate rapidly increases endothelial barrier function independently of VE-cadherin but requires cell spreading and Rho kinase.
15800053	Am. J. Physiol., Cell Physiol.	2005	Oberst MD et al.	HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease.
15590895	Am. J. Physiol., Cell Physiol.	2005	Lee MS et al.	Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells.
16267108	Am. J. Physiol., Cell Physiol.	2006	Kim MY et al.	Sphingosine-1-phosphate activates BKCa channels independently of G protein-coupled receptor in human endothelial cells.
16956968	Am. J. Physiol., Cell Physiol.	2007	Leiber D et al.	Exogenous sphingosine 1-phosphate and sphingosine kinase activated by endothelin-1 induced myometrial contraction through differential mechanisms.
16943246	Am. J. Physiol., Cell Physiol.	2007	Igarashi J et al.	Hydrogen peroxide induces S1P1 receptors and sensitizes vascular endothelial cells to sphingosine 1-phosphate, a platelet-derived lipid mediator.