rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

References related to genes published in Am. J. Physiol., Cell Physiol.


PMIDJournalPublished DateAuthorTitle
12055072Am. J. Physiol., Cell Physiol.2002Kilpatrick LE et al.A role for PKC-delta and PI 3-kinase in TNF-alpha-mediated antiapoptotic signaling in the human neutrophil.
12388079Am. J. Physiol., Cell Physiol.2003Liedtke CM et al.Stability of actin cytoskeleton and PKC-delta binding to actin regulate NKCC1 function in airway epithelial cells.
11078718Am. J. Physiol., Cell Physiol.2000Kilpatrick LE et al.Serine phosphorylation of p60 tumor necrosis factor receptor by PKC-delta in TNF-alpha-activated neutrophils.
18160487Am. J. Physiol., Cell Physiol.2008Ramnath RD et al.Role of PKC-delta on substance P-induced chemokine synthesis in pancreatic acinar cells.
17151144Am. J. Physiol., Cell Physiol.2007Hassan HA et al.Regulation of anion exchanger Slc26a6 by protein kinase C.