nystatin

nystatin is a lipid of Polyketides (PK) class. Nystatin is associated with abnormalities such as Virus Diseases, Infection, Candidiasis, Leukopenia and Mycoses. The involved functions are known as Membrane Potentials, Uptake, Flow or discharge, Cell membrane potential and adenine transport. Nystatin often locates in Cell Wall, Plasma membrane, Extracellular, Membrane and Virion. The associated genes with nystatin are Genome, Integral Membrane Proteins, Amino Acids, Basic, P4HTM gene and Homologous Gene. The related lipids are Sterols, Liposomes, Membrane Lipids, Sphingolipids and 1,2-oleoylphosphatidylcholine. The related experimental models are Knock-out and Xenograft Model.

References related to abnormalities published in Antimicrob. Agents Chemother.

PMID	Journal	Published Date	Author	Title
10223948	Antimicrob. Agents Chemother.	1999	Oakley KL et al.	Comparison of in vitro activity of liposomal nystatin against Aspergillus species with those of nystatin, amphotericin B (AB) deoxycholate, AB colloidal dispersion, liposomal AB, AB lipid complex, and itraconazole.
9624486	Antimicrob. Agents Chemother.	1998	Johnson EM et al.	Comparison of in vitro antifungal activities of free and liposome-encapsulated nystatin with those of four amphotericin B formulations.
10543734	Antimicrob. Agents Chemother.	1999	Denning DW and Warn P	Dose range evaluation of liposomal nystatin and comparisons with amphotericin B and amphotericin B lipid complex in temporarily neutropenic mice infected with an isolate of Aspergillus fumigatus with reduced susceptibility to amphotericin B.
10508025	Antimicrob. Agents Chemother.	1999	Groll AH et al.	Safety and efficacy of multilamellar liposomal nystatin against disseminated candidiasis in persistently neutropenic rabbits.
10348764	Antimicrob. Agents Chemother.	1999	Ramaswamy M et al.	Species differences in the proportion of plasma lipoprotein lipid carried by high-density lipoproteins influence the distribution of free and liposomal nystatin in human, dog, and rat plasma.
11959606	Antimicrob. Agents Chemother.	2002	González GM et al.	In vitro activities of free and lipid formulations of amphotericin B and nystatin against clinical isolates of Coccidioides immitis at various saprobic stages.
10722496	Antimicrob. Agents Chemother.	2000	Groll AH et al.	Compartmental pharmacokinetics and tissue distribution of multilamellar liposomal nystatin in rabbits.
14638502	Antimicrob. Agents Chemother.	2003	Groll AH et al.	Comparative drug disposition, urinary pharmacokinetics, and renal effects of multilamellar liposomal nystatin and amphotericin B deoxycholate in rabbits.
17893158	Antimicrob. Agents Chemother.	2007	Randhawa P et al.	BK Virus replication in vitro: limited effect of drugs interfering with viral uptake and intracellular transport.
15561860	Antimicrob. Agents Chemother.	2004	Offner F et al.	Liposomal nystatin in patients with invasive aspergillosis refractory to or intolerant of amphotericin B.
16048981	Antimicrob. Agents Chemother.	2005	Razonable RR et al.	Nystatin induces secretion of interleukin (IL)-1beta, IL-8, and tumor necrosis factor alpha by a toll-like receptor-dependent mechanism.
23716057	Antimicrob. Agents Chemother.	2013	Tevyashova AN et al.	Structure-antifungal activity relationships of polyene antibiotics of the amphotericin B group.