Ergosterol

Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.

References related to abnormalities published in Antimicrob. Agents Chemother.


PMIDJournalPublished DateAuthorTitle
12384344Antimicrob. Agents Chemother.2002Rogers PD and Barker KSEvaluation of differential gene expression in fluconazole-susceptible and -resistant isolates of Candida albicans by cDNA microarray analysis.
12760897Antimicrob. Agents Chemother.2003Urbina JA et al.Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease.
12878497Antimicrob. Agents Chemother.2003Sanglard D et al.Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents.
20733039Antimicrob. Agents Chemother.2010Martel CM et al.Identification and characterization of four azole-resistant erg3 mutants of Candida albicans.
20194694Antimicrob. Agents Chemother.2010Gamarra S et al.Mechanism of the synergistic effect of amiodarone and fluconazole in Candida albicans.
17875991Antimicrob. Agents Chemother.2007Siddiqui R et al.Effect of antimicrobial compounds on Balamuthia mandrillaris encystment and human brain microvascular endothelial cell cytopathogenicity.
15047513Antimicrob. Agents Chemother.2004Song JL et al.The Candida albicans lanosterol 14-alpha-demethylase (ERG11) gene promoter is maximally induced after prolonged growth with antifungal drugs.
15388421Antimicrob. Agents Chemother.2004Munayyer HK et al.Posaconazole is a potent inhibitor of sterol 14alpha-demethylation in yeasts and molds.
16723593Antimicrob. Agents Chemother.2006Osborne CS et al.Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine.
22615281Antimicrob. Agents Chemother.2012Hull CM et al.Facultative sterol uptake in an ergosterol-deficient clinical isolate of Candida glabrata harboring a missense mutation in ERG11 and exhibiting cross-resistance to azoles and amphotericin B.
22252817Antimicrob. Agents Chemother.2012Fang Y et al.A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis.
23689724Antimicrob. Agents Chemother.2013Lafleur MD et al.Potentiation of azole antifungals by 2-adamantanamine.
23147730Antimicrob. Agents Chemother.2013Sun N et al.Azole susceptibility and transcriptome profiling in Candida albicans mitochondrial electron transport chain complex I mutants.
24492373Antimicrob. Agents Chemother.2014Benaim G et al.Dronedarone, an amiodarone analog with improved anti-Leishmania mexicana efficacy.
26248360Antimicrob. Agents Chemother.2015Keller P et al.An Antifungal Benzimidazole Derivative Inhibits Ergosterol Biosynthesis and Reveals Novel Sterols.
25666149Antimicrob. Agents Chemother.2015Luna-Tapia A et al.Trafficking through the late endosome significantly impacts Candida albicans tolerance of the azole antifungals.
24614379Antimicrob. Agents Chemother.2014Ghelardi E et al.Potential of Ergosterol synthesis inhibitors to cause resistance or cross-resistance in Trichophyton rubrum.