nystatin

nystatin is a lipid of Polyketides (PK) class. Nystatin is associated with abnormalities such as Virus Diseases, Infection, Candidiasis, Leukopenia and Mycoses. The involved functions are known as Membrane Potentials, Uptake, Flow or discharge, Cell membrane potential and adenine transport. Nystatin often locates in Cell Wall, Plasma membrane, Extracellular, Membrane and Virion. The associated genes with nystatin are Genome, Integral Membrane Proteins, Amino Acids, Basic, P4HTM gene and Homologous Gene. The related lipids are Sterols, Liposomes, Membrane Lipids, Sphingolipids and 1,2-oleoylphosphatidylcholine. The related experimental models are Knock-out and Xenograft Model.

References related to functions published in Antimicrob. Agents Chemother.

PMID	Journal	Published Date	Author	Title
10223948	Antimicrob. Agents Chemother.	1999	Oakley KL et al.	Comparison of in vitro activity of liposomal nystatin against Aspergillus species with those of nystatin, amphotericin B (AB) deoxycholate, AB colloidal dispersion, liposomal AB, AB lipid complex, and itraconazole.
9624486	Antimicrob. Agents Chemother.	1998	Johnson EM et al.	Comparison of in vitro antifungal activities of free and liposome-encapsulated nystatin with those of four amphotericin B formulations.
10543734	Antimicrob. Agents Chemother.	1999	Denning DW and Warn P	Dose range evaluation of liposomal nystatin and comparisons with amphotericin B and amphotericin B lipid complex in temporarily neutropenic mice infected with an isolate of Aspergillus fumigatus with reduced susceptibility to amphotericin B.
11557469	Antimicrob. Agents Chemother.	2001	Ostrosky-Zeichner L et al.	Differential antifungal activity of isomeric forms of nystatin.
11959606	Antimicrob. Agents Chemother.	2002	González GM et al.	In vitro activities of free and lipid formulations of amphotericin B and nystatin against clinical isolates of Coccidioides immitis at various saprobic stages.
10722496	Antimicrob. Agents Chemother.	2000	Groll AH et al.	Compartmental pharmacokinetics and tissue distribution of multilamellar liposomal nystatin in rabbits.
14638502	Antimicrob. Agents Chemother.	2003	Groll AH et al.	Comparative drug disposition, urinary pharmacokinetics, and renal effects of multilamellar liposomal nystatin and amphotericin B deoxycholate in rabbits.
20385867	Antimicrob. Agents Chemother.	2010	te Welscher YM et al.	Natamycin inhibits vacuole fusion at the priming phase via a specific interaction with ergosterol.
17620378	Antimicrob. Agents Chemother.	2007	Serfling A et al.	Treatment of a clinically relevant plant-pathogenic fungus with an agricultural azole causes cross-resistance to medical azoles and potentiates caspofungin efficacy.
15561860	Antimicrob. Agents Chemother.	2004	Offner F et al.	Liposomal nystatin in patients with invasive aspergillosis refractory to or intolerant of amphotericin B.
16251298	Antimicrob. Agents Chemother.	2005	Sletta H et al.	Nystatin biosynthesis and transport: nysH and nysG genes encoding a putative ABC transporter system in Streptomyces noursei ATCC 11455 are required for efficient conversion of 10-deoxynystatin to nystatin.
15504830	Antimicrob. Agents Chemother.	2004	Bruheim P et al.	Chemical diversity of polyene macrolides produced by Streptomyces noursei ATCC 11455 and recombinant strain ERD44 with genetically altered polyketide synthase NysC.
16048981	Antimicrob. Agents Chemother.	2005	Razonable RR et al.	Nystatin induces secretion of interleukin (IL)-1beta, IL-8, and tumor necrosis factor alpha by a toll-like receptor-dependent mechanism.