clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

References related to genes published in Antimicrob. Agents Chemother.


PMIDJournalPublished DateAuthorTitle
9559810Antimicrob. Agents Chemother.1998Cheng KL et al.Effect of grapefruit juice on clarithromycin pharmacokinetics.
9687409Antimicrob. Agents Chemother.1998Portaels F et al.In vitro susceptibility of Mycobacterium ulcerans to clarithromycin.
9593146Antimicrob. Agents Chemother.1998Carr RA et al.Steady-state pharmacokinetics and electrocardiographic pharmacodynamics of clarithromycin and loratadine after individual or concomitant administration.
12019085Antimicrob. Agents Chemother.2002Finch R et al.Randomized controlled trial of sequential intravenous (i.v.) and oral moxifloxacin compared with sequential i.v. and oral co-amoxiclav with or without clarithromycin in patients with community-acquired pneumonia requiring initial parenteral treatment.
12069981Antimicrob. Agents Chemother.2002Svensson M et al.Pharmacodynamic effects of nitroimidazoles alone and in combination with clarithromycin on Helicobacter pylori.
12821476Antimicrob. Agents Chemother.2003van Zanten SJ et al.Gastric transitional zones, areas where Helicobacter treatment fails: results of a treatment trial using the Sydney strain mouse model.
12435674Antimicrob. Agents Chemother.2002Fontana C et al.New site of modification of 23S rRNA associated with clarithromycin resistance of Helicobacter pylori clinical isolates.
11120942Antimicrob. Agents Chemother.2001Ichiyama T et al.Clarithromycin inhibits NF-kappaB activation in human peripheral blood mononuclear cells and pulmonary epithelial cells.
10991834Antimicrob. Agents Chemother.2000Bermudez LE et al.Clarithromycin-resistant mycobacterium avium is still susceptible to treatment with clarithromycin and is virulent in mice.
9660986Antimicrob. Agents Chemother.1998Amsden GW et al.Oral cimetidine prolongs clarithromycin absorption.
15328128Antimicrob. Agents Chemother.2004Khan R et al.T2182C mutation in 23S rRNA is associated with clarithromycin resistance in Helicobacter pylori isolates obtained in Bangladesh.
15561865Antimicrob. Agents Chemother.2004Kim JM et al.Distribution of antibiotic MICs for Helicobacter pylori strains over a 16-year period in patients from Seoul, South Korea.
15504839Antimicrob. Agents Chemother.2004Berg HF et al.Emergence and persistence of macrolide resistance in oropharyngeal flora and elimination of nasal carriage of Staphylococcus aureus after therapy with slow-release clarithromycin: a randomized, double-blind, placebo-controlled study.
16048962Antimicrob. Agents Chemother.2005Dai G et al.Bactericidal and morphological effects of NE-2001, a novel synthetic agent directed against Helicobacter pylori.
15673794Antimicrob. Agents Chemother.2005Burucoa C et al.T2182C mutation is not associated with clarithromycin resistance in Helicobacter pylori.
22564837Antimicrob. Agents Chemother.2012Spyridaki A et al.Effect of clarithromycin in inflammatory markers of patients with ventilator-associated pneumonia and sepsis caused by Gram-negative bacteria: results from a randomized clinical study.
23545534Antimicrob. Agents Chemother.2013Alhajlan M et al.Efficacy and safety of liposomal clarithromycin and its effect on Pseudomonas aeruginosa virulence factors.