Ergosterol

Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.

References related to lipids published in Antimicrob. Agents Chemother.


PMIDJournalPublished DateAuthorTitle
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20733039Antimicrob. Agents Chemother.2010Martel CM et al.Identification and characterization of four azole-resistant erg3 mutants of Candida albicans.
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18056285Antimicrob. Agents Chemother.2008Pasrija R et al.Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.
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15047513Antimicrob. Agents Chemother.2004Song JL et al.The Candida albicans lanosterol 14-alpha-demethylase (ERG11) gene promoter is maximally induced after prolonged growth with antifungal drugs.
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16966400Antimicrob. Agents Chemother.2006Chau AS et al.Molecular basis for enhanced activity of posaconazole against Absidia corymbifera and Rhizopus oryzae.
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22615281Antimicrob. Agents Chemother.2012Hull CM et al.Facultative sterol uptake in an ergosterol-deficient clinical isolate of Candida glabrata harboring a missense mutation in ERG11 and exhibiting cross-resistance to azoles and amphotericin B.
22006005Antimicrob. Agents Chemother.2012Blosser SJ and Cramer RASREBP-dependent triazole susceptibility in Aspergillus fumigatus is mediated through direct transcriptional regulation of erg11A (cyp51A).
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24867980Antimicrob. Agents Chemother.2014Whaley SG et al.UPC2A is required for high-level azole antifungal resistance in Candida glabrata.