clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

References related to locations published in Antimicrob. Agents Chemother.

PMID	Journal	Published Date	Author	Title
10223952	Antimicrob. Agents Chemother.	1999	Fish DN and Abraham E	Pharmacokinetics of a clarithromycin suspension administered via nasogastric tube to seriously ill patients.
9593154	Antimicrob. Agents Chemother.	1998	Sörberg M et al.	Risk of development of in vitro resistance to amoxicillin, clarithromycin, and metronidazole in Helicobacter pylori.
11796367	Antimicrob. Agents Chemother.	2002	Tomioka H et al.	Intramacrophage passage of Mycobacterium tuberculosis and M. avium complex alters the drug susceptibilities of the organisms as determined by intracellular susceptibility testing using macrophages and type II alveolar epithelial cells.
12069981	Antimicrob. Agents Chemother.	2002	Svensson M et al.	Pharmacodynamic effects of nitroimidazoles alone and in combination with clarithromycin on Helicobacter pylori.
12821476	Antimicrob. Agents Chemother.	2003	van Zanten SJ et al.	Gastric transitional zones, areas where Helicobacter treatment fails: results of a treatment trial using the Sydney strain mouse model.
12709330	Antimicrob. Agents Chemother.	2003	Hardy RD et al.	Antimicrobial and immunologic activities of clarithromycin in a murine model of Mycoplasma pneumoniae-induced pneumonia.
12435674	Antimicrob. Agents Chemother.	2002	Fontana C et al.	New site of modification of 23S rRNA associated with clarithromycin resistance of Helicobacter pylori clinical isolates.
12435719	Antimicrob. Agents Chemother.	2002	Noreddin AM et al.	Pharmacodynamic modeling of clarithromycin against macrolide-resistant [PCR-positive mef(A) or erm(B)] Streptococcus pneumoniae simulating clinically achievable serum and epithelial lining fluid free-drug concentrations.
10991834	Antimicrob. Agents Chemother.	2000	Bermudez LE et al.	Clarithromycin-resistant mycobacterium avium is still susceptible to treatment with clarithromycin and is virulent in mice.
19414584	Antimicrob. Agents Chemother.	2009	Abduljalil K et al.	Modeling the autoinhibition of clarithromycin metabolism during repeated oral administration.
17606673	Antimicrob. Agents Chemother.	2007	Traunmüller F et al.	Pharmacokinetics of single- and multiple-dose oral clarithromycin in soft tissues determined by microdialysis.
15561865	Antimicrob. Agents Chemother.	2004	Kim JM et al.	Distribution of antibiotic MICs for Helicobacter pylori strains over a 16-year period in patients from Seoul, South Korea.
15504839	Antimicrob. Agents Chemother.	2004	Berg HF et al.	Emergence and persistence of macrolide resistance in oropharyngeal flora and elimination of nasal carriage of Staphylococcus aureus after therapy with slow-release clarithromycin: a randomized, double-blind, placebo-controlled study.
16048933	Antimicrob. Agents Chemother.	2005	Mathis A et al.	Mitochondrial ribosome as the target for the macrolide antibiotic clarithromycin in the helminth Echinococcus multilocularis.
15917564	Antimicrob. Agents Chemother.	2005	Kim YC et al.	Effect of CYP3A1(23) induction on clarithromycin pharmacokinetics in rats with diabetes mellitus.
16569825	Antimicrob. Agents Chemother.	2006	Dean NC et al.	Comparing gatifloxacin and clarithromycin in pneumonia symptom resolution and process of care.
18606842	Antimicrob. Agents Chemother.	2008	Rimbara E et al.	Novel mutation in 23S rRNA that confers low-level resistance to clarithromycin in Helicobacter pylori.
18779356	Antimicrob. Agents Chemother.	2008	Cirioni O et al.	Efficacy of the combination of tachyplesin III and clarithromycin in rat models of Escherichia coli sepsis.
22564837	Antimicrob. Agents Chemother.	2012	Spyridaki A et al.	Effect of clarithromycin in inflammatory markers of patients with ventilator-associated pneumonia and sepsis caused by Gram-negative bacteria: results from a randomized clinical study.
23545534	Antimicrob. Agents Chemother.	2013	Alhajlan M et al.	Efficacy and safety of liposomal clarithromycin and its effect on Pseudomonas aeruginosa virulence factors.