Ergosterol

Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.

References related to locations published in Antimicrob. Agents Chemother.


PMIDJournalPublished DateAuthorTitle
12384344Antimicrob. Agents Chemother.2002Rogers PD and Barker KSEvaluation of differential gene expression in fluconazole-susceptible and -resistant isolates of Candida albicans by cDNA microarray analysis.
12435664Antimicrob. Agents Chemother.2002Mukhopadhyay K et al.Drug susceptibilities of yeast cells are affected by membrane lipid composition.
12936965Antimicrob. Agents Chemother.2003Young LY et al.Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae.
10770760Antimicrob. Agents Chemother.2000Bammert GF and Fostel JMGenome-wide expression patterns in Saccharomyces cerevisiae: comparison of drug treatments and genetic alterations affecting biosynthesis of ergosterol.
10898679Antimicrob. Agents Chemother.2000Arthington-Skaggs BA et al.Quantitation of Candida albicans ergosterol content improves the correlation between in vitro antifungal susceptibility test results and in vivo outcome after fluconazole treatment in a murine model of invasive candidiasis.
15105135Antimicrob. Agents Chemother.2004Mukhopadhyay K et al.Membrane sphingolipid-ergosterol interactions are important determinants of multidrug resistance in Candida albicans.
20733039Antimicrob. Agents Chemother.2010Martel CM et al.Identification and characterization of four azole-resistant erg3 mutants of Candida albicans.
20194694Antimicrob. Agents Chemother.2010Gamarra S et al.Mechanism of the synergistic effect of amiodarone and fluconazole in Candida albicans.
20145080Antimicrob. Agents Chemother.2010Hoehamer CF et al.Changes in the proteome of Candida albicans in response to azole, polyene, and echinocandin antifungal agents.
22290956Antimicrob. Agents Chemother.2012Santos JR et al.Dynamic interaction between fluconazole and amphotericin B against Cryptococcus gattii.
18056285Antimicrob. Agents Chemother.2008Pasrija R et al.Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.
17875991Antimicrob. Agents Chemother.2007Siddiqui R et al.Effect of antimicrobial compounds on Balamuthia mandrillaris encystment and human brain microvascular endothelial cell cytopathogenicity.
15388421Antimicrob. Agents Chemother.2004Munayyer HK et al.Posaconazole is a potent inhibitor of sterol 14alpha-demethylation in yeasts and molds.
15388447Antimicrob. Agents Chemother.2004Markovich S et al.Genomic approach to identification of mutations affecting caspofungin susceptibility in Saccharomyces cerevisiae.
15855491Antimicrob. Agents Chemother.2005MacPherson S et al.Candida albicans zinc cluster protein Upc2p confers resistance to antifungal drugs and is an activator of ergosterol biosynthetic genes.
16966398Antimicrob. Agents Chemother.2006Khot PD et al.A small subpopulation of blastospores in candida albicans biofilms exhibit resistance to amphotericin B associated with differential regulation of ergosterol and beta-1,6-glucan pathway genes.
16954314Antimicrob. Agents Chemother.2006Prasad T et al.Unexpected link between iron and drug resistance of Candida spp.: iron depletion enhances membrane fluidity and drug diffusion, leading to drug-susceptible cells.
18694952Antimicrob. Agents Chemother.2008Vandeputte P et al.A nonsense mutation in the ERG6 gene leads to reduced susceptibility to polyenes in a clinical isolate of Candida glabrata.
22615281Antimicrob. Agents Chemother.2012Hull CM et al.Facultative sterol uptake in an ergosterol-deficient clinical isolate of Candida glabrata harboring a missense mutation in ERG11 and exhibiting cross-resistance to azoles and amphotericin B.
22006005Antimicrob. Agents Chemother.2012Blosser SJ and Cramer RASREBP-dependent triazole susceptibility in Aspergillus fumigatus is mediated through direct transcriptional regulation of erg11A (cyp51A).
22252817Antimicrob. Agents Chemother.2012Fang Y et al.A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis.
21746957Antimicrob. Agents Chemother.2011Burger-Kentischer A et al.A screening assay based on host-pathogen interaction models identifies a set of novel antifungal benzimidazole derivatives.
23459484Antimicrob. Agents Chemother.2013Kaneko Y et al.Real-time microscopic observation of Candida biofilm development and effects due to micafungin and fluconazole.
23459486Antimicrob. Agents Chemother.2013Tatsumi Y et al.Mechanism of action of efinaconazole, a novel triazole antifungal agent.
23629718Antimicrob. Agents Chemother.2013Eddouzi J et al.Molecular mechanisms of drug resistance in clinical Candida species isolated from Tunisian hospitals.
23147730Antimicrob. Agents Chemother.2013Sun N et al.Azole susceptibility and transcriptome profiling in Candida albicans mitochondrial electron transport chain complex I mutants.
23979757Antimicrob. Agents Chemother.2013Thomas E et al.Mitochondria influence CDR1 efflux pump activity, Hog1-mediated oxidative stress pathway, iron homeostasis, and ergosterol levels in Candida albicans.
24492373Antimicrob. Agents Chemother.2014Benaim G et al.Dronedarone, an amiodarone analog with improved anti-Leishmania mexicana efficacy.
25155595Antimicrob. Agents Chemother.2014Mesa-Arango AC et al.The production of reactive oxygen species is a universal action mechanism of Amphotericin B against pathogenic yeasts and contributes to the fungicidal effect of this drug.
27161631Antimicrob. Agents Chemother.2016Warrilow AG et al.The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme.
26248360Antimicrob. Agents Chemother.2015Keller P et al.An Antifungal Benzimidazole Derivative Inhibits Ergosterol Biosynthesis and Reveals Novel Sterols.
25666149Antimicrob. Agents Chemother.2015Luna-Tapia A et al.Trafficking through the late endosome significantly impacts Candida albicans tolerance of the azole antifungals.
24867980Antimicrob. Agents Chemother.2014Whaley SG et al.UPC2A is required for high-level azole antifungal resistance in Candida glabrata.