Ergosterol

Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.

References related to pathways published in Antimicrob. Agents Chemother.


PMIDJournalPublished DateAuthorTitle
10543744Antimicrob. Agents Chemother.1999Marichal P et al.Accumulation of 3-ketosteroids induced by itraconazole in azole-resistant clinical Candida albicans isolates.
10543759Antimicrob. Agents Chemother.1999Sanglard D et al.The ATP binding cassette transporter gene CgCDR1 from Candida glabrata is involved in the resistance of clinical isolates to azole antifungal agents.
10770760Antimicrob. Agents Chemother.2000Bammert GF and Fostel JMGenome-wide expression patterns in Saccharomyces cerevisiae: comparison of drug treatments and genetic alterations affecting biosynthesis of ergosterol.
10991846Antimicrob. Agents Chemother.2000Henry KW et al.Upregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitors.
12384344Antimicrob. Agents Chemother.2002Rogers PD and Barker KSEvaluation of differential gene expression in fluconazole-susceptible and -resistant isolates of Candida albicans by cDNA microarray analysis.
12435664Antimicrob. Agents Chemother.2002Mukhopadhyay K et al.Drug susceptibilities of yeast cells are affected by membrane lipid composition.
12878497Antimicrob. Agents Chemother.2003Sanglard D et al.Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents.
12936965Antimicrob. Agents Chemother.2003Young LY et al.Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae.
15047513Antimicrob. Agents Chemother.2004Song JL et al.The Candida albicans lanosterol 14-alpha-demethylase (ERG11) gene promoter is maximally induced after prolonged growth with antifungal drugs.
15388421Antimicrob. Agents Chemother.2004Munayyer HK et al.Posaconazole is a potent inhibitor of sterol 14alpha-demethylation in yeasts and molds.
15388447Antimicrob. Agents Chemother.2004Markovich S et al.Genomic approach to identification of mutations affecting caspofungin susceptibility in Saccharomyces cerevisiae.
15855491Antimicrob. Agents Chemother.2005MacPherson S et al.Candida albicans zinc cluster protein Upc2p confers resistance to antifungal drugs and is an activator of ergosterol biosynthetic genes.
16723593Antimicrob. Agents Chemother.2006Osborne CS et al.Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine.
16954314Antimicrob. Agents Chemother.2006Prasad T et al.Unexpected link between iron and drug resistance of Candida spp.: iron depletion enhances membrane fluidity and drug diffusion, leading to drug-susceptible cells.
16966398Antimicrob. Agents Chemother.2006Khot PD et al.A small subpopulation of blastospores in candida albicans biofilms exhibit resistance to amphotericin B associated with differential regulation of ergosterol and beta-1,6-glucan pathway genes.
17875991Antimicrob. Agents Chemother.2007Siddiqui R et al.Effect of antimicrobial compounds on Balamuthia mandrillaris encystment and human brain microvascular endothelial cell cytopathogenicity.
18056285Antimicrob. Agents Chemother.2008Pasrija R et al.Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.
18694952Antimicrob. Agents Chemother.2008Vandeputte P et al.A nonsense mutation in the ERG6 gene leads to reduced susceptibility to polyenes in a clinical isolate of Candida glabrata.
18779358Antimicrob. Agents Chemother.2008Fillinger S et al.Genetic analysis of fenhexamid-resistant field isolates of the phytopathogenic fungus Botrytis cinerea.
19380598Antimicrob. Agents Chemother.2009Vandeputte P et al.Hypersusceptibility to azole antifungals in a clinical isolate of Candida glabrata with reduced aerobic growth.
20194694Antimicrob. Agents Chemother.2010Gamarra S et al.Mechanism of the synergistic effect of amiodarone and fluconazole in Candida albicans.
20733039Antimicrob. Agents Chemother.2010Martel CM et al.Identification and characterization of four azole-resistant erg3 mutants of Candida albicans.
21078937Antimicrob. Agents Chemother.2011Hoot SJ et al.An A643V amino acid substitution in Upc2p contributes to azole resistance in well-characterized clinical isolates of Candida albicans.
21746957Antimicrob. Agents Chemother.2011Burger-Kentischer A et al.A screening assay based on host-pathogen interaction models identifies a set of novel antifungal benzimidazole derivatives.
22006003Antimicrob. Agents Chemother.2012Dhamgaye S et al.In vitro effect of malachite green on Candida albicans involves multiple pathways and transcriptional regulators UPC2 and STP2.
22006005Antimicrob. Agents Chemother.2012Blosser SJ and Cramer RASREBP-dependent triazole susceptibility in Aspergillus fumigatus is mediated through direct transcriptional regulation of erg11A (cyp51A).
22252817Antimicrob. Agents Chemother.2012Fang Y et al.A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis.
22615281Antimicrob. Agents Chemother.2012Hull CM et al.Facultative sterol uptake in an ergosterol-deficient clinical isolate of Candida glabrata harboring a missense mutation in ERG11 and exhibiting cross-resistance to azoles and amphotericin B.
23147730Antimicrob. Agents Chemother.2013Sun N et al.Azole susceptibility and transcriptome profiling in Candida albicans mitochondrial electron transport chain complex I mutants.
23459486Antimicrob. Agents Chemother.2013Tatsumi Y et al.Mechanism of action of efinaconazole, a novel triazole antifungal agent.
23629718Antimicrob. Agents Chemother.2013Eddouzi J et al.Molecular mechanisms of drug resistance in clinical Candida species isolated from Tunisian hospitals.
23689724Antimicrob. Agents Chemother.2013Lafleur MD et al.Potentiation of azole antifungals by 2-adamantanamine.
23979757Antimicrob. Agents Chemother.2013Thomas E et al.Mitochondria influence CDR1 efflux pump activity, Hog1-mediated oxidative stress pathway, iron homeostasis, and ergosterol levels in Candida albicans.
9756759Antimicrob. Agents Chemother.1998Marr KA et al.Rapid, transient fluconazole resistance in Candida albicans is associated with increased mRNA levels of CDR.