Lysophosphatidylcholine

Lysophosphatidylcholine is a lipid of Glycerophospholipids (GP) class. Lysophosphatidylcholine is associated with abnormalities such as Ischemia, Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Fatty Liver and Atherosclerosis. The involved functions are known as Inflammation, antagonists, Signal Transduction, Signal Pathways and Saturated. Lysophosphatidylcholine often locates in Body tissue, Head, integral to membrane, Membrane and Extracellular. The associated genes with Lysophosphatidylcholine are RHOA gene, Homologous Gene, GPR4 gene, GPR68 gene and TRPV2 gene. The related lipids are Nonesterified Fatty Acids, lysophosphatidylethanolamine, Lysophosphatidylcholines, Phosphatidylserines and 25-hydroxycholesterol. The related experimental models are Knock-out and Disease model.

References related to abnormalities published in Arterioscler. Thromb. Vasc. Biol.


PMIDJournalPublished DateAuthorTitle
16931794Arterioscler. Thromb. Vasc. Biol.2006Clavreul N et al.S-glutathiolation of p21ras by peroxynitrite mediates endothelial insulin resistance caused by oxidized low-density lipoprotein.
27127201Arterioscler. Thromb. Vasc. Biol.2016Li X et al.Mitochondrial Reactive Oxygen Species Mediate Lysophosphatidylcholine-Induced Endothelial Cell Activation.
19520973Arterioscler. Thromb. Vasc. Biol.2009Tan M et al.Lysophosphatidylcholine activates a novel PKD2-mediated signaling pathway that controls monocyte migration.
16990555Arterioscler. Thromb. Vasc. Biol.2006Parks BW et al.Loss of the lysophosphatidylcholine effector, G2A, ameliorates aortic atherosclerosis in low-density lipoprotein receptor knockout mice.
15331428Arterioscler. Thromb. Vasc. Biol.2004Zhang B et al.Inhibition of cholesteryl ester transfer protein activity by JTT-705 increases apolipoprotein E-containing high-density lipoprotein and favorably affects the function and enzyme composition of high-density lipoprotein in rabbits.
12482833Arterioscler. Thromb. Vasc. Biol.2002Rikitake Y et al.Expression of G2A, a receptor for lysophosphatidylcholine, by macrophages in murine, rabbit, and human atherosclerotic plaques.
10764665Arterioscler. Thromb. Vasc. Biol.2000Rikitake Y et al.Lysophosphatidylcholine inhibits endothelial cell migration and proliferation via inhibition of the extracellular signal-regulated kinase pathway.
10521373Arterioscler. Thromb. Vasc. Biol.1999Hahnel D et al.Role of plasmalogens in the enhanced resistance of LDL to copper-induced oxidation after LDL apheresis.