cholesterol

cholesterol is a lipid of Sterol Lipids (ST) class. Cholesterol is associated with abnormalities such as Trypanosomiasis, Chagas Disease, Cleft Palate, Chondrodysplasia punctata 2, X-linked dominant and Child syndrome. The involved functions are known as Blood Circulation, Sterol Biosynthesis Pathway, Receptor Mediated Endocytosis, Methylation and Signal. Cholesterol often locates in Animal tissue, Blood, Membrane, Plasma membrane and peroxisome. The associated genes with cholesterol are MBD2 gene, SIM, SLC33A1 gene, Genome and NSDHL gene. The related lipids are Sterols, zymosterol, fecosterol, Total cholesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out, Genetically Engineered Mouse and Disease model.

References related to abnormalities published in Arterioscler. Thromb. Vasc. Biol.


PMIDJournalPublished DateAuthorTitle
7773735Arterioscler. Thromb. Vasc. Biol.1995Retzinger GSAdsorption and coagulability of fibrinogen on atheromatous lipid surfaces.
7670952Arterioscler. Thromb. Vasc. Biol.1995Maor I et al.Macrophage uptake of oxidized LDL inhibits lysosomal sphingomyelinase, thus causing the accumulation of unesterified cholesterol-sphingomyelin-rich particles in the lysosomes. A possible role for 7-Ketocholesterol.
8548414Arterioscler. Thromb. Vasc. Biol.1996Hasler-Rapacz J et al.Effects of simvastatin on plasma lipids and apolipoproteins in familial hypercholesterolemic swine.
7600114Arterioscler. Thromb. Vasc. Biol.1995Sulistiyani SJ et al.Effect of 17 alpha-dihydroequilin sulfate, a conjugated equine estrogen, and ethynylestradiol on atherosclerosis in cholesterol-fed rabbits.
9409290Arterioscler. Thromb. Vasc. Biol.1997Miura S et al.Cholesterol-mediated changes of neutral cholesterol esterase activity in macrophages. Mechanism for mobilization of cholesteryl esters in lipid droplets by HDL.
8857917Arterioscler. Thromb. Vasc. Biol.1996Jones PJ et al.Dietary cholesterol feeding suppresses human cholesterol synthesis measured by deuterium incorporation and urinary mevalonic acid levels.
9108782Arterioscler. Thromb. Vasc. Biol.1997Phillips GB et al.Relationship between serum sex hormones and coronary artery disease in postmenopausal women.
9108794Arterioscler. Thromb. Vasc. Biol.1997Krut LH et al.The effect of oxidizing cholesterol on gastrointestinal absorption, plasma clearance, tissue distribution, and processing by endothelial cells.
9081680Arterioscler. Thromb. Vasc. Biol.1997Colli S et al.Vastatins inhibit tissue factor in cultured human macrophages. A novel mechanism of protection against atherothrombosis.
9555860Arterioscler. Thromb. Vasc. Biol.1998Westman J et al.Sterol 27-hydroxylase- and apoAI/phospholipid-mediated efflux of cholesterol from cholesterol-laden macrophages: evidence for an inverse relation between the two mechanisms.
7749833Arterioscler. Thromb. Vasc. Biol.1995Notarbartolo A et al.Inhibition of thromboxane biosynthesis and platelet function by simvastatin in type IIa hypercholesterolemia.
7749870Arterioscler. Thromb. Vasc. Biol.1995Adams MR et al.Effects of androgens on coronary artery atherosclerosis and atherosclerosis-related impairment of vascular responsiveness.
9672065Arterioscler. Thromb. Vasc. Biol.1998Deckert V et al.Inhibition by cholesterol oxides of NO release from human vascular endothelial cells.
9633929Arterioscler. Thromb. Vasc. Biol.1998Alexandersen P et al.Norethindrone acetate enhances the antiatherogenic effect of 17beta-estradiol: a secondary prevention study of aortic atherosclerosis in ovariectomized cholesterol-fed rabbits.
10446073Arterioscler. Thromb. Vasc. Biol.1999Brehme U et al.Aortic plaque size and endometrial response in cholesterol-fed rabbits treated with estrogen plus continuous or sequential progestin.
11397718Arterioscler. Thromb. Vasc. Biol.2001Volger OL et al.Dietary plant stanol esters reduce VLDL cholesterol secretion and bile saturation in apolipoprotein E*3-Leiden transgenic mice.
12117727Arterioscler. Thromb. Vasc. Biol.2002von Bahr S et al.Mechanism of accumulation of cholesterol and cholestanol in tendons and the role of sterol 27-hydroxylase (CYP27A1).
11950694Arterioscler. Thromb. Vasc. Biol.2002Huber J et al.Oxidized cholesteryl linoleates stimulate endothelial cells to bind monocytes via the extracellular signal-regulated kinase 1/2 pathway.
12615663Arterioscler. Thromb. Vasc. Biol.2003Rozenberg O et al.Human serum paraoxonase 1 decreases macrophage cholesterol biosynthesis: possible role for its phospholipase-A2-like activity and lysophosphatidylcholine formation.
10807752Arterioscler. Thromb. Vasc. Biol.2000Miettinen TA et al.Noncholesterol sterols and cholesterol lowering by long-term simvastatin treatment in coronary patients: relation to basal serum cholestanol.
10807761Arterioscler. Thromb. Vasc. Biol.2000Teede HJ et al.Postmenopausal hormone replacement therapy increases coagulation activity and fibrinolysis.
14592846Arterioscler. Thromb. Vasc. Biol.2004Micheletta F et al.Vitamin E supplementation in patients with carotid atherosclerosis: reversal of altered oxidative stress status in plasma but not in plaque.
15237091Arterioscler. Thromb. Vasc. Biol.2004Kontush A et al.Vitamin E is not deficient in human atherosclerotic plaques.
14726413Arterioscler. Thromb. Vasc. Biol.2004Suzuki S et al.Verapamil increases the apolipoprotein-mediated release of cellular cholesterol by induction of ABCA1 expression via Liver X receptor-independent mechanism.
14764421Arterioscler. Thromb. Vasc. Biol.2004Björkhem I and Meaney SBrain cholesterol: long secret life behind a barrier.
14764424Arterioscler. Thromb. Vasc. Biol.2004Devaraj S et al.Plant sterol-fortified orange juice effectively lowers cholesterol levels in mildly hypercholesterolemic healthy individuals.
20884874Arterioscler. Thromb. Vasc. Biol.2010Persson L et al.Circulating proprotein convertase subtilisin kexin type 9 has a diurnal rhythm synchronous with cholesterol synthesis and is reduced by fasting in humans.
17641249Arterioscler. Thromb. Vasc. Biol.2007Liu R et al.Phospholipid transfer protein-deficient mice absorb less cholesterol.
18340009Arterioscler. Thromb. Vasc. Biol.2008Parini P et al.Cholesterol synthesis inhibition elicits an integrated molecular response in human livers including decreased ACAT2.
18369155Arterioscler. Thromb. Vasc. Biol.2008Ouimet M et al.Epoxycholesterol impairs cholesteryl ester hydrolysis in macrophage foam cells, resulting in decreased cholesterol efflux.
15576644Arterioscler. Thromb. Vasc. Biol.2004Bjorkhem I and Diczfalusy U24(S),25-epoxycholesterol--a potential friend.
15618546Arterioscler. Thromb. Vasc. Biol.2005Wu B et al.Paradoxical effects of statins on aortic valve myofibroblasts and osteoblasts: implications for end-stage valvular heart disease.
16210564Arterioscler. Thromb. Vasc. Biol.2005Telford DE et al.A novel inhibitor of oxidosqualene:lanosterol cyclase inhibits very low-density lipoprotein apolipoprotein B100 (apoB100) production and enhances low-density lipoprotein apoB100 catabolism through marked reduction in hepatic cholesterol content.
15514210Arterioscler. Thromb. Vasc. Biol.2004Wong J et al.Statins inhibit synthesis of an oxysterol ligand for the liver x receptor in human macrophages with consequences for cholesterol flux.
15499044Arterioscler. Thromb. Vasc. Biol.2005Dove DE et al.ACAT1 deficiency disrupts cholesterol efflux and alters cellular morphology in macrophages.
18599800Arterioscler. Thromb. Vasc. Biol.2008Burgess B et al.Overexpression of human ABCG1 does not affect atherosclerosis in fat-fed ApoE-deficient mice.
23139291Arterioscler. Thromb. Vasc. Biol.2013Briand F et al.Upregulating reverse cholesterol transport with cholesteryl ester transfer protein inhibition requires combination with the LDL-lowering drug berberine in dyslipidemic hamsters.