7-Ketocholesterol

7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.

References related to abnormalities published in Arterioscler. Thromb. Vasc. Biol.


PMIDJournalPublished DateAuthorTitle
10938019Arterioscler. Thromb. Vasc. Biol.2000Liao HS et al.Expression of class A scavenger receptor inhibits apoptosis of macrophages triggered by oxidized low density lipoprotein and oxysterol.
20395595Arterioscler. Thromb. Vasc. Biol.2010Li D et al.Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction.
15458974Arterioscler. Thromb. Vasc. Biol.2004Martinet W et al.7-ketocholesterol induces protein ubiquitination, myelin figure formation, and light chain 3 processing in vascular smooth muscle cells.
23702662Arterioscler. Thromb. Vasc. Biol.2013Siragusa M and Sessa WCTelmisartan exerts pleiotropic effects in endothelial cells and promotes endothelial cell quiescence and survival.