Lysophosphatidylcholine

Lysophosphatidylcholine is a lipid of Glycerophospholipids (GP) class. Lysophosphatidylcholine is associated with abnormalities such as Ischemia, Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Fatty Liver and Atherosclerosis. The involved functions are known as Inflammation, antagonists, Signal Transduction, Signal Pathways and Saturated. Lysophosphatidylcholine often locates in Body tissue, Head, integral to membrane, Membrane and Extracellular. The associated genes with Lysophosphatidylcholine are RHOA gene, Homologous Gene, GPR4 gene, GPR68 gene and TRPV2 gene. The related lipids are Nonesterified Fatty Acids, lysophosphatidylethanolamine, Lysophosphatidylcholines, Phosphatidylserines and 25-hydroxycholesterol. The related experimental models are Knock-out and Disease model.

References related to functions published in Arterioscler. Thromb. Vasc. Biol.

PMID	Journal	Published Date	Author	Title
11397700	Arterioscler. Thromb. Vasc. Biol.	2001	Yasunari K et al.	HMG-CoA reductase inhibitors prevent migration of human coronary smooth muscle cells through suppression of increase in oxidative stress.
16931794	Arterioscler. Thromb. Vasc. Biol.	2006	Clavreul N et al.	S-glutathiolation of p21ras by peroxynitrite mediates endothelial insulin resistance caused by oxidized low-density lipoprotein.
16990555	Arterioscler. Thromb. Vasc. Biol.	2006	Parks BW et al.	Loss of the lysophosphatidylcholine effector, G2A, ameliorates aortic atherosclerosis in low-density lipoprotein receptor knockout mice.
15331428	Arterioscler. Thromb. Vasc. Biol.	2004	Zhang B et al.	Inhibition of cholesteryl ester transfer protein activity by JTT-705 increases apolipoprotein E-containing high-density lipoprotein and favorably affects the function and enzyme composition of high-density lipoprotein in rabbits.
12006386	Arterioscler. Thromb. Vasc. Biol.	2002	Yamakawa T et al.	Lysophosphatidylcholine activates extracellular signal-regulated kinases 1/2 through reactive oxygen species in rat vascular smooth muscle cells.
11348873	Arterioscler. Thromb. Vasc. Biol.	2001	Morimoto M et al.	Lysophosphatidylcholine induces early growth response factor-1 expression and activates the core promoter of PDGF-A chain in vascular endothelial cells.
10591684	Arterioscler. Thromb. Vasc. Biol.	1999	Dichtl W et al.	Oxidized LDL and lysophosphatidylcholine stimulate plasminogen activator inhibitor-1 expression in vascular smooth muscle cells.
10521373	Arterioscler. Thromb. Vasc. Biol.	1999	Hahnel D et al.	Role of plasmalogens in the enhanced resistance of LDL to copper-induced oxidation after LDL apheresis.
10397691	Arterioscler. Thromb. Vasc. Biol.	1999	Sakai M et al.	Glucocorticoid inhibits oxidized LDL-induced macrophage growth by suppressing the expression of granulocyte/macrophage colony-stimulating factor.
9672081	Arterioscler. Thromb. Vasc. Biol.	1998	Ramos MA et al.	Induction of macrophage VEGF in response to oxidized LDL and VEGF accumulation in human atherosclerotic lesions.
9555869	Arterioscler. Thromb. Vasc. Biol.	1998	Wu R et al.	Lysophosphatidylcholine is involved in the antigenicity of oxidized LDL.
9301636	Arterioscler. Thromb. Vasc. Biol.	1997	Miwa Y et al.	Lysophosphatidylcholine inhibits receptor-mediated Ca2+ mobilization in intact endothelial cells of rabbit aorta.
8620332	Arterioscler. Thromb. Vasc. Biol.	1996	Stiko A et al.	Active oxygen species and lysophosphatidylcholine are involved in oxidized low density lipoprotein activation of smooth muscle cell DNA synthesis.