7-Ketocholesterol

7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.

References related to functions published in Arterioscler. Thromb. Vasc. Biol.

PMID	Journal	Published Date	Author	Title
7583578	Arterioscler. Thromb. Vasc. Biol.	1995	Sugiyama S et al.	Lipoproteins regulate C-type natriuretic peptide secretion from cultured vascular endothelial cells.
10195944	Arterioscler. Thromb. Vasc. Biol.	1999	van Reyk DM et al.	Prooxidant and antioxidant activities of macrophages in metal-mediated LDL oxidation: the importance of metal sequestration.
10938019	Arterioscler. Thromb. Vasc. Biol.	2000	Liao HS et al.	Expression of class A scavenger receptor inhibits apoptosis of macrophages triggered by oxidized low density lipoprotein and oxysterol.
20395595	Arterioscler. Thromb. Vasc. Biol.	2010	Li D et al.	Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction.
15458974	Arterioscler. Thromb. Vasc. Biol.	2004	Martinet W et al.	7-ketocholesterol induces protein ubiquitination, myelin figure formation, and light chain 3 processing in vascular smooth muscle cells.
23702662	Arterioscler. Thromb. Vasc. Biol.	2013	Siragusa M and Sessa WC	Telmisartan exerts pleiotropic effects in endothelial cells and promotes endothelial cell quiescence and survival.