Lysophosphatidylcholine

Lysophosphatidylcholine is a lipid of Glycerophospholipids (GP) class. Lysophosphatidylcholine is associated with abnormalities such as Ischemia, Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Fatty Liver and Atherosclerosis. The involved functions are known as Inflammation, antagonists, Signal Transduction, Signal Pathways and Saturated. Lysophosphatidylcholine often locates in Body tissue, Head, integral to membrane, Membrane and Extracellular. The associated genes with Lysophosphatidylcholine are RHOA gene, Homologous Gene, GPR4 gene, GPR68 gene and TRPV2 gene. The related lipids are Nonesterified Fatty Acids, lysophosphatidylethanolamine, Lysophosphatidylcholines, Phosphatidylserines and 25-hydroxycholesterol. The related experimental models are Knock-out and Disease model.

References related to lipids published in Arterioscler. Thromb. Vasc. Biol.

PMID	Journal	Published Date	Author	Title
16931794	Arterioscler. Thromb. Vasc. Biol.	2006	Clavreul N et al.	S-glutathiolation of p21ras by peroxynitrite mediates endothelial insulin resistance caused by oxidized low-density lipoprotein.
16990555	Arterioscler. Thromb. Vasc. Biol.	2006	Parks BW et al.	Loss of the lysophosphatidylcholine effector, G2A, ameliorates aortic atherosclerosis in low-density lipoprotein receptor knockout mice.
15331428	Arterioscler. Thromb. Vasc. Biol.	2004	Zhang B et al.	Inhibition of cholesteryl ester transfer protein activity by JTT-705 increases apolipoprotein E-containing high-density lipoprotein and favorably affects the function and enzyme composition of high-density lipoprotein in rabbits.
15178563	Arterioscler. Thromb. Vasc. Biol.	2004	Takabe W et al.	Lysophosphatidylcholine enhances cytokine production of endothelial cells via induction of L-type amino acid transporter 1 and cell surface antigen 4F2.
11348873	Arterioscler. Thromb. Vasc. Biol.	2001	Morimoto M et al.	Lysophosphatidylcholine induces early growth response factor-1 expression and activates the core promoter of PDGF-A chain in vascular endothelial cells.
10845869	Arterioscler. Thromb. Vasc. Biol.	2000	Memon RA et al.	Infection and inflammation induce LDL oxidation in vivo.
10591684	Arterioscler. Thromb. Vasc. Biol.	1999	Dichtl W et al.	Oxidized LDL and lysophosphatidylcholine stimulate plasminogen activator inhibitor-1 expression in vascular smooth muscle cells.
10521373	Arterioscler. Thromb. Vasc. Biol.	1999	Hahnel D et al.	Role of plasmalogens in the enhanced resistance of LDL to copper-induced oxidation after LDL apheresis.
8620332	Arterioscler. Thromb. Vasc. Biol.	1996	Stiko A et al.	Active oxygen species and lysophosphatidylcholine are involved in oxidized low density lipoprotein activation of smooth muscle cell DNA synthesis.