cholesterol

cholesterol is a lipid of Sterol Lipids (ST) class. Cholesterol is associated with abnormalities such as Trypanosomiasis, Chagas Disease, Cleft Palate, Chondrodysplasia punctata 2, X-linked dominant and Child syndrome. The involved functions are known as Blood Circulation, Sterol Biosynthesis Pathway, Receptor Mediated Endocytosis, Methylation and Signal. Cholesterol often locates in Animal tissue, Blood, Membrane, Plasma membrane and peroxisome. The associated genes with cholesterol are MBD2 gene, SIM, SLC33A1 gene, Genome and NSDHL gene. The related lipids are Sterols, zymosterol, fecosterol, Total cholesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out, Genetically Engineered Mouse and Disease model.

References related to pathways published in Arterioscler. Thromb. Vasc. Biol.


PMIDJournalPublished DateAuthorTitle
11397718Arterioscler. Thromb. Vasc. Biol.2001Volger OL et al.Dietary plant stanol esters reduce VLDL cholesterol secretion and bile saturation in apolipoprotein E*3-Leiden transgenic mice.
12615663Arterioscler. Thromb. Vasc. Biol.2003Rozenberg O et al.Human serum paraoxonase 1 decreases macrophage cholesterol biosynthesis: possible role for its phospholipase-A2-like activity and lysophosphatidylcholine formation.
14726413Arterioscler. Thromb. Vasc. Biol.2004Suzuki S et al.Verapamil increases the apolipoprotein-mediated release of cellular cholesterol by induction of ABCA1 expression via Liver X receptor-independent mechanism.
14764421Arterioscler. Thromb. Vasc. Biol.2004Björkhem I and Meaney SBrain cholesterol: long secret life behind a barrier.
15514210Arterioscler. Thromb. Vasc. Biol.2004Wong J et al.Statins inhibit synthesis of an oxysterol ligand for the liver x receptor in human macrophages with consequences for cholesterol flux.
15576644Arterioscler. Thromb. Vasc. Biol.2004Bjorkhem I and Diczfalusy U24(S),25-epoxycholesterol--a potential friend.
15591221Arterioscler. Thromb. Vasc. Biol.2005Sakamoto K et al.Fluvastatin prevents vascular hyperplasia by inhibiting phenotype modulation and proliferation through extracellular signal-regulated kinase 1 and 2 and p38 mitogen-activated protein kinase inactivation in organ-cultured artery.
15618546Arterioscler. Thromb. Vasc. Biol.2005Wu B et al.Paradoxical effects of statins on aortic valve myofibroblasts and osteoblasts: implications for end-stage valvular heart disease.
16210564Arterioscler. Thromb. Vasc. Biol.2005Telford DE et al.A novel inhibitor of oxidosqualene:lanosterol cyclase inhibits very low-density lipoprotein apolipoprotein B100 (apoB100) production and enhances low-density lipoprotein apoB100 catabolism through marked reduction in hepatic cholesterol content.
17641249Arterioscler. Thromb. Vasc. Biol.2007Liu R et al.Phospholipid transfer protein-deficient mice absorb less cholesterol.
17761942Arterioscler. Thromb. Vasc. Biol.2007Heverin M et al.Studies on the cholesterol-free mouse: strong activation of LXR-regulated hepatic genes when replacing cholesterol with desmosterol.
18369155Arterioscler. Thromb. Vasc. Biol.2008Ouimet M et al.Epoxycholesterol impairs cholesteryl ester hydrolysis in macrophage foam cells, resulting in decreased cholesterol efflux.
18599800Arterioscler. Thromb. Vasc. Biol.2008Burgess B et al.Overexpression of human ABCG1 does not affect atherosclerosis in fat-fed ApoE-deficient mice.
23139291Arterioscler. Thromb. Vasc. Biol.2013Briand F et al.Upregulating reverse cholesterol transport with cholesteryl ester transfer protein inhibition requires combination with the LDL-lowering drug berberine in dyslipidemic hamsters.
7670952Arterioscler. Thromb. Vasc. Biol.1995Maor I et al.Macrophage uptake of oxidized LDL inhibits lysosomal sphingomyelinase, thus causing the accumulation of unesterified cholesterol-sphingomyelin-rich particles in the lysosomes. A possible role for 7-Ketocholesterol.
7749833Arterioscler. Thromb. Vasc. Biol.1995Notarbartolo A et al.Inhibition of thromboxane biosynthesis and platelet function by simvastatin in type IIa hypercholesterolemia.
7749836Arterioscler. Thromb. Vasc. Biol.1995Kritharides L et al.Apolipoprotein A-I-mediated efflux of sterols from oxidized LDL-loaded macrophages.
7749852Arterioscler. Thromb. Vasc. Biol.1995Corsini A et al.Effects of 26-aminocholesterol, 27-hydroxycholesterol, and 25-hydroxycholesterol on proliferation and cholesterol homeostasis in arterial myocytes.
8857917Arterioscler. Thromb. Vasc. Biol.1996Jones PJ et al.Dietary cholesterol feeding suppresses human cholesterol synthesis measured by deuterium incorporation and urinary mevalonic acid levels.
9108794Arterioscler. Thromb. Vasc. Biol.1997Krut LH et al.The effect of oxidizing cholesterol on gastrointestinal absorption, plasma clearance, tissue distribution, and processing by endothelial cells.
9409290Arterioscler. Thromb. Vasc. Biol.1997Miura S et al.Cholesterol-mediated changes of neutral cholesterol esterase activity in macrophages. Mechanism for mobilization of cholesteryl esters in lipid droplets by HDL.
9555860Arterioscler. Thromb. Vasc. Biol.1998Westman J et al.Sterol 27-hydroxylase- and apoAI/phospholipid-mediated efflux of cholesterol from cholesterol-laden macrophages: evidence for an inverse relation between the two mechanisms.