Ganglioside GM2
Ganglioside GM2 is a lipid of Sphingolipids (SP) class. Ganglioside gm2 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Autoimmune Diseases, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating and Neuromuscular Diseases. The involved functions are known as Pressure- physical agent, Cytolysis, Inflammation, Complement-Dependent Cytotoxicity and conjugation. Ganglioside gm2 often locates in Membrane, Entire nervous system, Cell surface, Biopsy sample and Lipid Bilayers. The associated genes with Ganglioside GM2 are anti-IgM, Polypeptides, Transgenes, Alleles and Homologous Gene. The related lipids are Ganglioside GA2, QS 21, sulfate-3-glucuronyl paragloboside, Lipopolysaccharides and IV(4)-galactosyl-N-acetylganglioside GD1a. The related experimental models are Disease model.
References related to abnormalities published in Biochim. Biophys. Acta
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 12527415 | Biochim. Biophys. Acta | 2003 | Sharma R et al. | A single site in human beta-hexosaminidase A binds both 6-sulfate-groups on hexosamines and the sialic acid moiety of GM2 ganglioside. |
| 17967427 | Biochim. Biophys. Acta | 2008 | Li YT et al. | Effect of structural modifications of ganglioside GM2 on intra-molecular carbohydrate-to-carbohydrate interaction and enzymatic susceptibility. |
| 10571007 | Biochim. Biophys. Acta | 1999 | Mahuran DJ | Biochemical consequences of mutations causing the GM2 gangliosidoses. |
| 9217013 | Biochim. Biophys. Acta | 1997 | Yadao F et al. | Formation of a ternary complex between GM2 activator protein, GM2 ganglioside and hexosaminidase A. |
| 9187239 | Biochim. Biophys. Acta | 1997 | Smiljanic-Georgijev N et al. | Characterization of the affinity of the G(M2) activator protein for glycolipids by a fluorescence dequenching assay. |