Ganglioside GI

Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.

References related to abnormalities published in Biochim. Biophys. Acta


PMIDJournalPublished DateAuthorTitle
27552916Biochim. Biophys. Acta2016Prasanna X et al.The ganglioside GM1 interacts with the serotonin1A receptor via the sphingolipid binding domain.
26656159Biochim. Biophys. Acta2016Calamai M et al.Single molecule experiments emphasize GM1 as a key player of the different cytotoxicity of structurally distinct Aβ1-42 oligomers.
25101973Biochim. Biophys. Acta2015Šachl R et al.On multivalent receptor activity of GM1 in cholesterol containing membranes.
20937248Biochim. Biophys. Acta2011Gayen A et al.NMR evidence of GM1-induced conformational change of Substance P using isotropic bicelles.
19800863Biochim. Biophys. Acta2009Iglesias-Bartolomé R et al.Differential endocytic trafficking of neuropathy-associated antibodies to GM1 ganglioside and cholera toxin in epithelial and neural cells.
18727916Biochim. Biophys. Acta2008Yamamoto N et al.Age-dependent high-density clustering of GM1 ganglioside at presynaptic neuritic terminals promotes amyloid beta-protein fibrillogenesis.
17355906Biochim. Biophys. Acta2007Tanaka T et al.Biological roles of anti-GM1 antibodies in patients with Guillain-Barré syndrome for nerve growth factor signaling.
17321494Biochim. Biophys. Acta2007Yanagisawa KRole of gangliosides in Alzheimer's disease.
17306220Biochim. Biophys. Acta2007Yamamoto N et al.GM1-ganglioside-induced Abeta assembly on synaptic membranes of cultured neurons.
9315619Biochim. Biophys. Acta1997Ilangumaran S et al.Distinct interactions among GPI-anchored, transmembrane and membrane associated intracellular proteins, and sphingolipids in lymphocyte and endothelial cell plasma membranes.
27806911Biochim. Biophys. Acta2017Ruggiero FM et al.Membrane binding, endocytic trafficking and intracellular fate of high-affinity antibodies to gangliosides GD1a and GM1.
22206893Biochim. Biophys. Acta2012Viljetić B et al.Distribution of mono-, di- and trisialo gangliosides in the brain of Actinopterygian fishes.
15629689Biochim. Biophys. Acta2005Heffer-Lauc M et al.Membrane redistribution of gangliosides and glycosylphosphatidylinositol-anchored proteins in brain tissue sections under conditions of lipid raft isolation.
28143757Biochim. Biophys. Acta2017Manna M et al.Long-chain GM1 gangliosides alter transmembrane domain registration through interdigitation.
27102612Biochim. Biophys. Acta2016Kasimov MR et al.Similar oxysterols may lead to opposite effects on synaptic transmission: Olesoxime versus 5α-cholestan-3-one at the frog neuromuscular junction.
18155174Biochim. Biophys. Acta2008Anastasia L et al.Over-expression of mammalian sialidase NEU3 reduces Newcastle disease virus entry and propagation in COS7 cells.
18029096Biochim. Biophys. Acta2008Nores GA et al.Anti-GM1 antibodies as a model of the immune response to self-glycans.