Sphingosine 1-phosphate

Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.

References related to genes published in Blood


PMIDJournalPublished DateAuthorTitle
15070679Blood2004Langlois S et al.Membrane type 1-matrix metalloproteinase (MT1-MMP) cooperates with sphingosine 1-phosphate to induce endothelial cell migration and morphogenic differentiation.
11675357Blood2001Cuvillier O and Levade TSphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria.
11418470Blood2001Olorundare OE et al.Assembly of a fibronectin matrix by adherent platelets stimulated by lysophosphatidic acid and other agonists.
12730100Blood2003Takeya H et al.Synergistic effect of sphingosine 1-phosphate on thrombin-induced tissue factor expression in endothelial cells.
10753843Blood2000Van Brocklyn JR et al.Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6.
18988873Blood2008Severinson EWASp stings mature lymphocytes.
19139083Blood2009Gérard A et al.The Rac activator Tiam1 controls efficient T-cell trafficking and route of transendothelial migration.
20197547Blood2010Weigert A et al.Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells.
18541717Blood2008Yoon CM et al.Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways.
18178871Blood2008Oskeritzian CA et al.Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions.
18292290Blood2008Kunisawa J et al.Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.
18199826Blood2008Li X et al.Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1.
15741222Blood2005Yabu T et al.Thalidomide-induced antiangiogenic action is mediated by ceramide through depletion of VEGF receptors, and is antagonized by sphingosine-1-phosphate.
15870184Blood2005Halin C et al.The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches.
17234743Blood2007Kunisawa J et al.Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production.
22262738Blood2012Christopherson KWPBSCs Sphingoling along S1P/S1P1 axis.
22279055Blood2012Golan K et al.S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release.
23775711Blood2013Zhang L et al.Sphingosine kinase 2 (Sphk2) regulates platelet biogenesis by providing intracellular sphingosine 1-phosphate (S1P).
24235134Blood2014Speak AO et al.Altered distribution and function of natural killer cells in murine and human Niemann-Pick disease type C1.