trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

References related to functions published in Cancer Res.

PMID	Journal	Published Date	Author	Title
21978933	Cancer Res.	2011	Ward Y et al.	LPA receptor heterodimerizes with CD97 to amplify LPA-initiated RHO-dependent signaling and invasion in prostate cancer cells.
11245429	Cancer Res.	2001	Zhu WG et al.	DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors.
10945620	Cancer Res.	2000	Badia E et al.	Long-term hydroxytamoxifen treatment of an MCF-7-derived breast cancer cell line irreversibly inhibits the expression of estrogenic genes through chromatin remodeling.
9927053	Cancer Res.	1999	Saunders N et al.	Histone deacetylase inhibitors as potential anti-skin cancer agents.
15313918	Cancer Res.	2004	Myzak MC et al.	A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.
19047136	Cancer Res.	2008	Setiadi AF et al.	Epigenetic enhancement of antigen processing and presentation promotes immune recognition of tumors.
20332239	Cancer Res.	2010	Majid S et al.	Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.
18172295	Cancer Res.	2008	Heller G et al.	Genome-wide transcriptional response to 5-aza-2'-deoxycytidine and trichostatin a in multiple myeloma cells.
15781649	Cancer Res.	2005	Bai J et al.	Predominant Bcl-XL knockdown disables antiapoptotic mechanisms: tumor necrosis factor-related apoptosis-inducing ligand-based triple chemotherapy overcomes chemoresistance in pancreatic cancer cells in vitro.
15753377	Cancer Res.	2005	Mori T et al.	Epigenetic up-regulation of C-C chemokine receptor 7 and C-X-C chemokine receptor 4 expression in melanoma cells.
15604258	Cancer Res.	2004	Bayart E et al.	A major role for mitotic CDC2 kinase inactivation in the establishment of the mitotic DNA damage checkpoint.
16322213	Cancer Res.	2005	Wei M et al.	BRCA1 promoter methylation in sporadic breast cancer is associated with reduced BRCA1 copy number and chromosome 17 aneusomy.
16357148	Cancer Res.	2005	Noh EJ et al.	Methyl CpG-binding domain protein 3 mediates cancer-selective cytotoxicity by histone deacetylase inhibitors via differential transcriptional reprogramming in lung cancer cells.
16103091	Cancer Res.	2005	Blagosklonny MV et al.	Depletion of mutant p53 and cytotoxicity of histone deacetylase inhibitors.
15899819	Cancer Res.	2005	Ho WC et al.	Nuclear factor-kappaB induced by doxorubicin is deficient in phosphorylation and acetylation and represses nuclear factor-kappaB-dependent transcription in cancer cells.
15899836	Cancer Res.	2005	Tran T et al.	Enhancement of folate receptor alpha expression in tumor cells through the glucocorticoid receptor: a promising means to improved tumor detection and targeting.
16885346	Cancer Res.	2006	Kim TY et al.	Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma.
16818622	Cancer Res.	2006	Lau QC et al.	RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer.
16818640	Cancer Res.	2006	Foltz G et al.	Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma.
16818643	Cancer Res.	2006	Mori T et al.	Estrogen receptor-alpha methylation predicts melanoma progression.
16778215	Cancer Res.	2006	Sharma D et al.	Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes.
16707423	Cancer Res.	2006	Ibanez de Caceres I et al.	Identification of novel target genes by an epigenetic reactivation screen of renal cancer.
18757430	Cancer Res.	2008	Kim M et al.	LRRC3B, encoding a leucine-rich repeat-containing protein, is a putative tumor suppressor gene in gastric cancer.