Epothilone B
Epothilone B is a lipid of Polyketides (PK) class. Epothilone b is associated with abnormalities such as Myelosuppression, Measurable Disease, Neuropathy, Neutropenia and Thrombocytopenia. The involved functions are known as Cell Cycle Arrest, Apoptosis, Signal Transduction, Cytokinesis and Caspase Activation. Epothilone b often locates in Mitochondria, Cytoplasmic matrix, Microtubules, Spindle and Protoplasm. The associated genes with Epothilone B are TNFSF10 gene, DIABLO gene, FADD gene, BCL2 gene and BCL2L1 gene. The related lipids are Promega and Phosphatidylserines. The related experimental models are Xenograft Model and Mouse Model.
References related to locations published in Cancer Res.
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 12124345 | Cancer Res. | 2002 | Bröker LE et al. | Late activation of apoptotic pathways plays a negligible role in mediating the cytotoxic effects of discodermolide and epothilone B in non-small cell lung cancer cells. |
| 11929805 | Cancer Res. | 2002 | Chen JG and Horwitz SB | Differential mitotic responses to microtubule-stabilizing and -destabilizing drugs. |
| 12460910 | Cancer Res. | 2002 | Bocci G et al. | Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs. |
| 14729603 | Cancer Res. | 2004 | Bröker LE et al. | Cathepsin B mediates caspase-independent cell death induced by microtubule stabilizing agents in non-small cell lung cancer cells. |
| 19118001 | Cancer Res. | 2009 | Hopper-Borge E et al. | Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B. |
| 14522931 | Cancer Res. | 2003 | Kamath K and Jordan MA | Suppression of microtubule dynamics by epothilone B is associated with mitotic arrest. |