Cucurbitacin b is a lipid of Sterol Lipids (ST) class. Cucurbitacin b is associated with abnormalities such as Morphologically altered structure. The involved functions are known as Signal Transduction, Apoptosis, Cell Cycle Arrest, Cell Cycle and Negative Regulation of Mitosis. Cucurbitacin b often locates in Mediastinum and Pseudopodia. The associated genes with Cucurbitacin B are STAT5A gene, JAK2 gene, STAT3 gene, CDKN1A gene and BCL2L1 gene. The related experimental models are Xenograft Model.
PMID | Journal | Published Date | Author | Title |
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19605406 | Cancer Res. | 2009 | Thoennissen NH et al. | Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells. |