Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
References related to lipids published in Cardiovasc. Res.
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 19228708 | Cardiovasc. Res. | 2009 | Gellings Lowe N et al. | Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-beta-stimulated collagen production by cardiac fibroblasts. |
| 19233865 | Cardiovasc. Res. | 2009 | Igarashi J and Michel T | Sphingosine-1-phosphate and modulation of vascular tone. |
| 19218288 | Cardiovasc. Res. | 2009 | Choi SK et al. | Comparison of contractile mechanisms of sphingosylphosphorylcholine and sphingosine-1-phosphate in rabbit coronary artery. |
| 19700468 | Cardiovasc. Res. | 2010 | Frias MA et al. | Native and reconstituted HDL protect cardiomyocytes from doxorubicin-induced apoptosis. |
| 19017750 | Cardiovasc. Res. | 2009 | Karliner JS | Sphingosine kinase regulation and cardioprotection. |
| 19151362 | Cardiovasc. Res. | 2009 | Frias MA et al. | Native and reconstituted HDL activate Stat3 in ventricular cardiomyocytes via ERK1/2: role of sphingosine-1-phosphate. |
| 17331485 | Cardiovasc. Res. | 2007 | Yang Q | Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival. |
| 17320845 | Cardiovasc. Res. | 2007 | Tao R et al. | Deletion of the sphingosine kinase-1 gene influences cell fate during hypoxia and glucose deprivation in adult mouse cardiomyocytes. |
| 18411230 | Cardiovasc. Res. | 2008 | Dueñas AI et al. | Selective attenuation of Toll-like receptor 2 signalling may explain the atheroprotective effect of sphingosine 1-phosphate. |
| 16542647 | Cardiovasc. Res. | 2006 | Schubert R | Sphingosine-1-phosphate in the circulatory system: Cause and therapeutic target for vascular dysfunction? |
| 16533504 | Cardiovasc. Res. | 2006 | Scherer EQ et al. | Sphingosine-1-phosphate modulates spiral modiolar artery tone: A potential role in vascular-based inner ear pathologies? |
| 18480127 | Cardiovasc. Res. | 2008 | Takashima S et al. | G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase. |
| 18558630 | Cardiovasc. Res. | 2008 | Heller R et al. | Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells. |