Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
References related to pathways published in Cardiovasc. Res.
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 12667959 | Cardiovasc. Res. | 2003 | Ohmori T et al. | Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2. |
| 16542647 | Cardiovasc. Res. | 2006 | Schubert R | Sphingosine-1-phosphate in the circulatory system: Cause and therapeutic target for vascular dysfunction? |
| 17320845 | Cardiovasc. Res. | 2007 | Tao R et al. | Deletion of the sphingosine kinase-1 gene influences cell fate during hypoxia and glucose deprivation in adult mouse cardiomyocytes. |
| 17331485 | Cardiovasc. Res. | 2007 | Yang Q | Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival. |
| 18411230 | Cardiovasc. Res. | 2008 | Dueñas AI et al. | Selective attenuation of Toll-like receptor 2 signalling may explain the atheroprotective effect of sphingosine 1-phosphate. |
| 18558630 | Cardiovasc. Res. | 2008 | Heller R et al. | Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells. |
| 19017750 | Cardiovasc. Res. | 2009 | Karliner JS | Sphingosine kinase regulation and cardioprotection. |
| 19151362 | Cardiovasc. Res. | 2009 | Frias MA et al. | Native and reconstituted HDL activate Stat3 in ventricular cardiomyocytes via ERK1/2: role of sphingosine-1-phosphate. |
| 19218288 | Cardiovasc. Res. | 2009 | Choi SK et al. | Comparison of contractile mechanisms of sphingosylphosphorylcholine and sphingosine-1-phosphate in rabbit coronary artery. |
| 19228708 | Cardiovasc. Res. | 2009 | Gellings Lowe N et al. | Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-beta-stimulated collagen production by cardiac fibroblasts. |
| 19233865 | Cardiovasc. Res. | 2009 | Igarashi J and Michel T | Sphingosine-1-phosphate and modulation of vascular tone. |
| 19700468 | Cardiovasc. Res. | 2010 | Frias MA et al. | Native and reconstituted HDL protect cardiomyocytes from doxorubicin-induced apoptosis. |
| 23180720 | Cardiovasc. Res. | 2013 | Lidington D et al. | Capitalizing on diversity: an integrative approach towards the multiplicity of cellular mechanisms underlying myogenic responsiveness. |
| 23658376 | Cardiovasc. Res. | 2013 | Böhm A et al. | Factor-Xa-induced mitogenesis and migration require sphingosine kinase activity and S1P formation in human vascular smooth muscle cells. |