Epothilone B
Epothilone B is a lipid of Polyketides (PK) class. Epothilone b is associated with abnormalities such as Myelosuppression, Measurable Disease, Neuropathy, Neutropenia and Thrombocytopenia. The involved functions are known as Cell Cycle Arrest, Apoptosis, Signal Transduction, Cytokinesis and Caspase Activation. Epothilone b often locates in Mitochondria, Cytoplasmic matrix, Microtubules, Spindle and Protoplasm. The associated genes with Epothilone B are TNFSF10 gene, DIABLO gene, FADD gene, BCL2 gene and BCL2L1 gene. The related lipids are Promega and Phosphatidylserines. The related experimental models are Xenograft Model and Mouse Model.
References related to functions published in Clin. Cancer Res.
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 11350914 | Clin. Cancer Res. | 2001 | Lee FY et al. | BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy. |
| 19228735 | Clin. Cancer Res. | 2009 | Bley CR et al. | Role of the microenvironment for radiosensitization by patupilone. |
| 17634546 | Clin. Cancer Res. | 2007 | Forster M et al. | A phase Ib and pharmacokinetic trial of patupilone combined with carboplatin in patients with advanced cancer. |
| 15746064 | Clin. Cancer Res. | 2005 | Hofstetter B et al. | Patupilone acts as radiosensitizing agent in multidrug-resistant cancer cells in vitro and in vivo. |
| 16278399 | Clin. Cancer Res. | 2005 | Ferretti S et al. | Patupilone induced vascular disruption in orthotopic rodent tumor models detected by magnetic resonance imaging and interstitial fluid pressure. |