Epothilone B is a lipid of Polyketides (PK) class. Epothilone b is associated with abnormalities such as Myelosuppression, Measurable Disease, Neuropathy, Neutropenia and Thrombocytopenia. The involved functions are known as Cell Cycle Arrest, Apoptosis, Signal Transduction, Cytokinesis and Caspase Activation. Epothilone b often locates in Mitochondria, Cytoplasmic matrix, Microtubules, Spindle and Protoplasm. The associated genes with Epothilone B are TNFSF10 gene, DIABLO gene, FADD gene, BCL2 gene and BCL2L1 gene. The related lipids are Promega and Phosphatidylserines. The related experimental models are Xenograft Model and Mouse Model.
PMID | Journal | Published Date | Author | Title |
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19228735 | Clin. Cancer Res. | 2009 | Bley CR et al. | Role of the microenvironment for radiosensitization by patupilone. |
15746064 | Clin. Cancer Res. | 2005 | Hofstetter B et al. | Patupilone acts as radiosensitizing agent in multidrug-resistant cancer cells in vitro and in vivo. |
16278399 | Clin. Cancer Res. | 2005 | Ferretti S et al. | Patupilone induced vascular disruption in orthotopic rodent tumor models detected by magnetic resonance imaging and interstitial fluid pressure. |