erythromycin

erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.

References related to functions published in Drug Metab. Dispos.

PMID	Journal	Published Date	Author	Title
9806945	Drug Metab. Dispos.	1998	Yamazaki H and Shimada T	Comparative studies of in vitro inhibition of cytochrome P450 3A4-dependent testosterone 6beta-hydroxylation by roxithromycin and its metabolites, troleandomycin, and erythromycin.
11901100	Drug Metab. Dispos.	2002	Fowler SM et al.	CYP3A4 active site volume modification by mutagenesis of leucine 211.
12814962	Drug Metab. Dispos.	2003	Evans DC et al.	Eletriptan metabolism by human hepatic CYP450 enzymes and transport by human P-glycoprotein.
12814973	Drug Metab. Dispos.	2003	Ito K et al.	Prediction of the in vivo interaction between midazolam and macrolides based on in vitro studies using human liver microsomes.
10997945	Drug Metab. Dispos.	2000	Mushiroda T et al.	The involvement of flavin-containing monooxygenase but not CYP3A4 in metabolism of itopride hydrochloride, a gastroprokinetic agent: comparison with cisapride and mosapride citrate.
19741038	Drug Metab. Dispos.	2009	Lan T et al.	Interaction of macrolide antibiotics with intestinally expressed human and rat organic anion-transporting polypeptides.
21835977	Drug Metab. Dispos.	2011	Chen Y et al.	Determination of time-dependent inactivation of CYP3A4 in cryopreserved human hepatocytes and assessment of human drug-drug interactions.
18420780	Drug Metab. Dispos.	2008	McLaughlin LA et al.	Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.
16221752	Drug Metab. Dispos.	2006	Galetin A et al.	Prediction of time-dependent CYP3A4 drug-drug interactions: impact of enzyme degradation, parallel elimination pathways, and intestinal inhibition.
16679385	Drug Metab. Dispos.	2006	McGinnity DF et al.	Evaluation of time-dependent cytochrome P450 inhibition using cultured human hepatocytes.
18505790	Drug Metab. Dispos.	2008	Yasuda K et al.	A comprehensive in vitro and in silico analysis of antibiotics that activate pregnane X receptor and induce CYP3A4 in liver and intestine.