FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

References related to functions published in Drug Metab. Dispos.


PMIDJournalPublished DateAuthorTitle
12642459Drug Metab. Dispos.2003Khan KK et al.Homotropic versus heterotopic cooperativity of cytochrome P450eryF: a substrate oxidation and spectral titration study.
16443668Drug Metab. Dispos.2006Kim SK et al.The mitogen-activated protein kinase kinase (mek) inhibitor PD98059 elevates primary cultured rat hepatocyte glutathione levels independent of inhibiting mek.
19074529Drug Metab. Dispos.2009Si D et al.Mechanism of CYP2C9 inhibition by flavones and flavonols.
20843940Drug Metab. Dispos.2010Chen EP et al.A mechanism-based mathematical model of aryl hydrocarbon receptor-mediated CYP1A induction in rats using beta-naphthoflavone as a tool compound.
17664249Drug Metab. Dispos.2007Pham MH et al.Identification of new flavone-8-acetic acid metabolites using mouse microsomes and comparison with human microsomes.