chrysin is a lipid of Polyketides (PK) class. Chrysin is associated with abnormalities such as Unconjugated hyperbilirubinemia, Metabolic Diseases, Hypogonadism, Renal tubular disorder and Colitis. The involved functions are known as Hypoxia, enzyme activity, Oxidation, inhibitors and Cell Survival. Chrysin often locates in Protoplasm, Plasma membrane, Back, Extracellular and Mitochondria. The associated genes with chrysin are CFB gene, P4HTM gene, UGT1A9 gene, CYP1A1 gene and UGT1A1 gene. The related lipids are Promega, estradiol-3-glucuronide, Steroids and Lipopolysaccharides. The related experimental models are Mouse Model.
PMID | Journal | Published Date | Author | Title |
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11950788 | Drug Metab. Dispos. | 2002 | Walle UK and Walle T | Induction of human UDP-glucuronosyltransferase UGT1A1 by flavonoids-structural requirements. |
10950852 | Drug Metab. Dispos. | 2000 | Walle T et al. | Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in the human hepatoma cell line hep G2. |
15608138 | Drug Metab. Dispos. | 2005 | Zhang S et al. | Flavonoids chrysin and benzoflavone, potent breast cancer resistance protein inhibitors, have no significant effect on topotecan pharmacokinetics in rats or mdr1a/1b (-/-) mice. |
17093006 | Drug Metab. Dispos. | 2007 | Wang X and Morris ME | Effects of the flavonoid chrysin on nitrofurantoin pharmacokinetics in rats: potential involvement of ABCG2. |
19074529 | Drug Metab. Dispos. | 2009 | Si D et al. | Mechanism of CYP2C9 inhibition by flavones and flavonols. |
22357286 | Drug Metab. Dispos. | 2012 | Walsky RL et al. | Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors. |
25595598 | Drug Metab. Dispos. | 2015 | Quan E et al. | Characterization of chrysin glucuronidation in UGT1A1-overexpressing HeLa cells: elucidating the transporters responsible for efflux of glucuronide. |