quercetin

quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.

References related to genes published in Drug Metab. Dispos.

PMID	Journal	Published Date	Author	Title
12695340	Drug Metab. Dispos.	2003	Raucy JL	Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products.
12756216	Drug Metab. Dispos.	2003	Petri N et al.	Absorption/metabolism of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum in vivo.
15155557	Drug Metab. Dispos.	2004	Walsky RL and Obach RS	Validated assays for human cytochrome P450 activities.
21543555	Drug Metab. Dispos.	2011	Bolling BW et al.	Microsomal quercetin glucuronidation in rat small intestine depends on age and segment.
17293380	Drug Metab. Dispos.	2007	Ung D and Nagar S	Variable sulfation of dietary polyphenols by recombinant human sulfotransferase (SULT) 1A1 genetic variants and SULT1E1.
17478601	Drug Metab. Dispos.	2007	Williamson G et al.	Interaction of positional isomers of quercetin glucuronides with the transporter ABCC2 (cMOAT, MRP2).
17670841	Drug Metab. Dispos.	2007	Jancová P et al.	Silybin is metabolized by cytochrome P450 2C8 in vitro.
18094037	Drug Metab. Dispos.	2008	van de Kerkhof EG et al.	Induction of metabolism and transport in human intestine: validation of precision-cut slices as a tool to study induction of drug metabolism in human intestine in vitro.
15833931	Drug Metab. Dispos.	2005	Graf BA et al.	Disposition and metabolism of [2-14C]quercetin-4'-glucoside in rats.
15640378	Drug Metab. Dispos.	2005	Satoh H et al.	Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B.
16280456	Drug Metab. Dispos.	2006	Yang JH et al.	Inhibition of lung cancer cell growth by quercetin glucuronides via G2/M arrest and induction of apoptosis.
15483196	Drug Metab. Dispos.	2004	Schrag ML et al.	Sulfotransferase 1E1 is a low km isoform mediating the 3-O-sulfation of ethinyl estradiol.
15502008	Drug Metab. Dispos.	2005	Webb LJ et al.	Analysis of substrate specificities and tissue expression of rat UDP-glucuronosyltransferases UGT1A7 and UGT1A8.
17142561	Drug Metab. Dispos.	2007	O'Donnell CJ et al.	The development of a cocktail CYP2B6, CYP2C8, and CYP3A5 inhibition assay and a preliminary assessment of utility in a drug discovery setting.
16611861	Drug Metab. Dispos.	2006	Guo J et al.	Identification of human hepatic cytochrome P450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.).
22584252	Drug Metab. Dispos.	2012	Kim HG et al.	The increased cellular uptake and biliary excretion of curcumin by quercetin: a possible role of albumin binding interaction.
24065861	Drug Metab. Dispos.	2013	Zhuang XM et al.	Assessment of the roles of P-glycoprotein and cytochrome P450 in triptolide-induced liver toxicity in sandwich-cultured rat hepatocyte model.