chrysin

chrysin is a lipid of Polyketides (PK) class. Chrysin is associated with abnormalities such as Unconjugated hyperbilirubinemia, Metabolic Diseases, Hypogonadism, Renal tubular disorder and Colitis. The involved functions are known as Hypoxia, enzyme activity, Oxidation, inhibitors and Cell Survival. Chrysin often locates in Protoplasm, Plasma membrane, Back, Extracellular and Mitochondria. The associated genes with chrysin are CFB gene, P4HTM gene, UGT1A9 gene, CYP1A1 gene and UGT1A1 gene. The related lipids are Promega, estradiol-3-glucuronide, Steroids and Lipopolysaccharides. The related experimental models are Mouse Model.

References related to genes published in Drug Metab. Dispos.

PMID	Journal	Published Date	Author	Title
11950788	Drug Metab. Dispos.	2002	Walle UK and Walle T	Induction of human UDP-glucuronosyltransferase UGT1A1 by flavonoids-structural requirements.
10950852	Drug Metab. Dispos.	2000	Walle T et al.	Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in the human hepatoma cell line hep G2.
15608138	Drug Metab. Dispos.	2005	Zhang S et al.	Flavonoids chrysin and benzoflavone, potent breast cancer resistance protein inhibitors, have no significant effect on topotecan pharmacokinetics in rats or mdr1a/1b (-/-) mice.
17093006	Drug Metab. Dispos.	2007	Wang X and Morris ME	Effects of the flavonoid chrysin on nitrofurantoin pharmacokinetics in rats: potential involvement of ABCG2.
19074529	Drug Metab. Dispos.	2009	Si D et al.	Mechanism of CYP2C9 inhibition by flavones and flavonols.
19273529	Drug Metab. Dispos.	2009	Zhao R et al.	Breast cancer resistance protein interacts with various compounds in vitro, but plays a minor role in substrate efflux at the blood-brain barrier.
25595598	Drug Metab. Dispos.	2015	Quan E et al.	Characterization of chrysin glucuronidation in UGT1A1-overexpressing HeLa cells: elucidating the transporters responsible for efflux of glucuronide.