Sphingosine 1-phosphate

Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.

References related to abnormalities published in FASEB J.


PMIDJournalPublished DateAuthorTitle
11726541FASEB J.2001Rosenfeldt HM et al.EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration.
12087059FASEB J.2002Kohno T et al.N-glycans of sphingosine 1-phosphate receptor Edg-1 regulate ligand-induced receptor internalization.
12890700FASEB J.2003Gratzinger D et al.Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.
15208269FASEB J.2004Chavakis T et al.Regulation of neovascularization by human neutrophil peptides (alpha-defensins): a link between inflammation and angiogenesis.
15231724FASEB J.2004Maupas-Schwalm F et al.The sphingomyelin/ceramide pathway is involved in ERK1/2 phosphorylation, cell proliferation, and uPAR overexpression induced by tissue-type plasminogen activator.
15084513FASEB J.2004Wang W et al.Physiological sphingosine 1-phosphate requirement for optimal activity of mouse CD4+ regulatory T Cells.
14715694FASEB J.2004Gräler MH and Goetzl EJThe immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors.
21450910FASEB J.2011Brecht K et al.Macrophages programmed by apoptotic cells promote angiogenesis via prostaglandin E2.
18824518FASEB J.2009Kawamori T et al.Role for sphingosine kinase 1 in colon carcinogenesis.
19158154FASEB J.2009Liao JJ et al.Immunosuppressive human anti-lymphocyte autoantibodies specific for the type 1 sphingosine 1-phosphate receptor.
19535686FASEB J.2009Price MM et al.Sphingosine-1-phosphate induces development of functionally mature chymase-expressing human mast cells from hematopoietic progenitors.
20207939FASEB J.2010Xu R et al.Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes.
18245172FASEB J.2008Tan W et al.An essential role for Rac1 in endothelial cell function and vascular development.
15625079FASEB J.2005Donati C et al.Sphingosine 1-phosphate regulates myogenic differentiation: a major role for S1P2 receptor.
16319132FASEB J.2006Kawamori T et al.Sphingosine kinase 1 is up-regulated in colon carcinogenesis.
16940153FASEB J.2006Xu R et al.Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P.
16877527FASEB J.2006Dragusin M et al.Effects of sphingosine-1-phosphate and ceramide-1-phosphate on rat intestinal smooth muscle cells: implications for postoperative ileus.
16148028FASEB J.2005Fieger CB et al.Type 1 sphingosine 1-phosphate G protein-coupled receptor signaling of lymphocyte functions requires sulfation of its extracellular amino-terminal tyrosines.
18815359FASEB J.2009Snider AJ et al.A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis.
23629860FASEB J.2013Orr Gandy KA et al.Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation.