PSYCHOSINE

PSYCHOSINE is a lipid of Sphingolipids (SP) class. Psychosine is associated with abnormalities such as Globoid cell leukodystrophy, Demyelinating Diseases, Multiple Sclerosis, nervous system disorder and Lysosomal Storage Diseases. The involved functions are known as Ionization, Pathogenesis, Demyelination, 5-(carboxyamino)imidazole ribonucleotide mutase activity and Increased Sensitivy. Psychosine often locates in Body tissue, CNS - Brain (MMHCC), Autosome, Peripheral Nervous System and Nerve Tissue. The associated genes with PSYCHOSINE are GALC gene, NTRK1 gene, JUN gene, ALPP gene and Polylysine. The related lipids are Fatty Acids, fatty aldehyde, lysophosphatidic acid, Stearic acid and stearoyl chloride. The related experimental models are Mouse Model and Streptozotocin Diabetes.

References related to genes published in Hum. Mol. Genet.

PMID	Journal	Published Date	Author	Title
11726558	Hum. Mol. Genet.	2001	Matsuda J et al.	Dramatic phenotypic improvement during pregnancy in a genetic leukodystrophy: estrogen appears to be a critical factor.
11371512	Hum. Mol. Genet.	2001	Matsuda J et al.	A mutation in the saposin A domain of the sphingolipid activator protein (prosaposin) gene results in a late-onset, chronic form of globoid cell leukodystrophy in the mouse.
23620143	Hum. Mol. Genet.	2013	Potter GB et al.	Missense mutation in mouse GALC mimics human gene defect and offers new insights into Krabbe disease.
24064337	Hum. Mol. Genet.	2014	Farfel-Becker T et al.	Neuronal accumulation of glucosylceramide in a mouse model of neuronopathic Gaucher disease leads to neurodegeneration.