20-HETE

20-hete is a lipid of Fatty Acyls (FA) class. 20-hete is associated with abnormalities such as Cyst, Kidney Diseases, Kidney Failure, Chronic, Cystic Kidney Diseases and Simple renal cyst. The involved functions are known as Phosphorylation, inhibitors, Hypertrophy, Epithelial Cell Proliferation and Anabolism. 20-hete often locates in Mouse Kidney, Microsomes, Tissue membrane, Body tissue and Cytoplasmic matrix. The associated genes with 20-HETE are CYP4F3 gene, PKHD1 gene, Transgenes, P4HTM gene and CYP2E1 gene. The related lipids are Promega, enterodiol, Fatty Acids, hexanoic acid and U 73343. The related experimental models are Mouse Model, Knock-out, Streptozotocin Diabetes, Transgenic Model and Rodent Model.

References related to genes published in Hypertension

PMID	Journal	Published Date	Author	Title
9039121	Hypertension	1997	Stec DE et al.	Inhibition of renal outer medullary 20-HETE production produces hypertension in Lewis rats.
9931139	Hypertension	1999	Sun CW et al.	Role of tyrosine kinase and PKC in the vasoconstrictor response to 20-HETE in renal arterioles.
11882623	Hypertension	2002	Botros FT et al.	Regulation of cyclooxygenase- and cytochrome p450-derived eicosanoids by heme oxygenase in the rat kidney.
11230346	Hypertension	2001	Parmentier JH et al.	20-Hydroxyeicosatetraenoic acid mediates angiotensin ii-induced phospholipase d activation in vascular smooth muscle cells.
12623999	Hypertension	2003	Randriamboavonjy V et al.	20-HETE-induced contraction of small coronary arteries depends on the activation of Rho-kinase.
12900435	Hypertension	2003	Quilley J and Chen YJ	Role of COX-2 in the enhanced vasoconstrictor effect of arachidonic acid in the diabetic rat kidney.
14707157	Hypertension	2004	Laffer CL et al.	20-HETE and circulating insulin in essential hypertension with obesity.
21321301	Hypertension	2011	Wu CC et al.	Androgen-dependent hypertension is mediated by 20-hydroxy-5,8,11,14-eicosatetraenoic acid-induced vascular dysfunction: role of inhibitor of kappaB Kinase.
19786646	Hypertension	2009	Wu JH et al.	Inhibition of 20-hydroxyeicosatetraenoic acid synthesis using specific plant lignans: in vitro and human studies.
17548717	Hypertension	2007	Roman RJ and Lombard JH	Does 20-hydroxyeicosatetraenoic acid contribute to sex differences in cardiovascular risk by increasing oxidative stress?
17548721	Hypertension	2007	Singh H et al.	Vascular cytochrome P450 4A expression and 20-hydroxyeicosatetraenoic acid synthesis contribute to endothelial dysfunction in androgen-induced hypertension.
18227405	Hypertension	2008	Laffer CL et al.	The T8590C polymorphism of CYP4A11 and 20-hydroxyeicosatetraenoic acid in essential hypertension.
18391101	Hypertension	2008	Ward NC et al.	A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure.
15569854	Hypertension	2005	Zhang F et al.	Decreased levels of cytochrome P450 2E1-derived eicosanoids sensitize renal arteries to constrictor agonists in spontaneously hypertensive rats.
14967839	Hypertension	2004	Hoagland KM et al.	Elevated BSC-1 and ROMK expression in Dahl salt-sensitive rat kidneys.
15897359	Hypertension	2005	Yaghini FA et al.	Contribution of arachidonic acid metabolites derived via cytochrome P4504A to angiotensin II-induced neointimal growth.
15723968	Hypertension	2005	Dahly-Vernon AJ et al.	Transforming growth factor-beta, 20-HETE interaction, and glomerular injury in Dahl salt-sensitive rats.
17210834	Hypertension	2007	Williams JM et al.	Elevations in renal interstitial hydrostatic pressure and 20-hydroxyeicosatetraenoic acid contribute to pressure natriuresis.
18574070	Hypertension	2008	Fava C et al.	The V433M variant of the CYP4F2 is associated with ischemic stroke in male Swedes beyond its effect on blood pressure.
23753406	Hypertension	2013	Bubb KJ et al.	Activation of neuronal transient receptor potential vanilloid 1 channel underlies 20-hydroxyeicosatetraenoic acid-induced vasoactivity: role for protein kinase A.