20-HETE
20-hete is a lipid of Fatty Acyls (FA) class. 20-hete is associated with abnormalities such as Cyst, Kidney Diseases, Kidney Failure, Chronic, Cystic Kidney Diseases and Simple renal cyst. The involved functions are known as Phosphorylation, inhibitors, Hypertrophy, Epithelial Cell Proliferation and Anabolism. 20-hete often locates in Mouse Kidney, Microsomes, Tissue membrane, Body tissue and Cytoplasmic matrix. The associated genes with 20-HETE are CYP4F3 gene, PKHD1 gene, Transgenes, P4HTM gene and CYP2E1 gene. The related lipids are Promega, enterodiol, Fatty Acids, hexanoic acid and U 73343. The related experimental models are Mouse Model, Knock-out, Streptozotocin Diabetes, Transgenic Model and Rodent Model.
References related to pathways published in Hypertension
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 11230346 | Hypertension | 2001 | Parmentier JH et al. | 20-Hydroxyeicosatetraenoic acid mediates angiotensin ii-induced phospholipase d activation in vascular smooth muscle cells. |
| 12623983 | Hypertension | 2003 | Laffer CL et al. | 20-HETE and furosemide-induced natriuresis in salt-sensitive essential hypertension. |
| 12874093 | Hypertension | 2003 | Hoagland KM et al. | Inhibitors of 20-HETE formation promote salt-sensitive hypertension in rats. |
| 14707157 | Hypertension | 2004 | Laffer CL et al. | 20-HETE and circulating insulin in essential hypertension with obesity. |
| 15569854 | Hypertension | 2005 | Zhang F et al. | Decreased levels of cytochrome P450 2E1-derived eicosanoids sensitize renal arteries to constrictor agonists in spontaneously hypertensive rats. |
| 16043660 | Hypertension | 2005 | Huang A et al. | Contribution of 20-HETE to augmented myogenic constriction in coronary arteries of endothelial NO synthase knockout mice. |
| 17548717 | Hypertension | 2007 | Roman RJ and Lombard JH | Does 20-hydroxyeicosatetraenoic acid contribute to sex differences in cardiovascular risk by increasing oxidative stress? |
| 17548721 | Hypertension | 2007 | Singh H et al. | Vascular cytochrome P450 4A expression and 20-hydroxyeicosatetraenoic acid synthesis contribute to endothelial dysfunction in androgen-induced hypertension. |
| 18227405 | Hypertension | 2008 | Laffer CL et al. | The T8590C polymorphism of CYP4A11 and 20-hydroxyeicosatetraenoic acid in essential hypertension. |
| 19786646 | Hypertension | 2009 | Wu JH et al. | Inhibition of 20-hydroxyeicosatetraenoic acid synthesis using specific plant lignans: in vitro and human studies. |
| 21321301 | Hypertension | 2011 | Wu CC et al. | Androgen-dependent hypertension is mediated by 20-hydroxy-5,8,11,14-eicosatetraenoic acid-induced vascular dysfunction: role of inhibitor of kappaB Kinase. |
| 23753406 | Hypertension | 2013 | Bubb KJ et al. | Activation of neuronal transient receptor potential vanilloid 1 channel underlies 20-hydroxyeicosatetraenoic acid-induced vasoactivity: role for protein kinase A. |
| 9453309 | Hypertension | 1998 | Pratt PF et al. | 20-HETE relaxes bovine coronary arteries through the release of prostacyclin. |
| 9931139 | Hypertension | 1999 | Sun CW et al. | Role of tyrosine kinase and PKC in the vasoconstrictor response to 20-HETE in renal arterioles. |