rotenone

rotenone is a lipid of Polyketides (PK) class. Rotenone is associated with abnormalities such as Parkinson Disease, MYOPATHY, DISTAL, WITH ANTERIOR TIBIAL ONSET, Neurodegenerative Disorders, Septicemia and Respiratory Failure. The involved functions are known as Phosphorylation, Process, Cell Death, proteasome activity and Apoptosis. Rotenone often locates in Protoplasm, Presynaptic Terminals, Neurites, NADH dehydrogenase complex and Mitochondria. The associated genes with rotenone are DNAJB9 gene, EIF2S3 gene, Candidate Disease Gene, G-substrate and ERN1 gene. The related lipids are Lipopolysaccharides, Membrane Lipids, Phosphatidylserines, Fatty Acids and Cardiolipins. The related experimental models are Knock-out, Mouse Model, Disease model and Rodent Model.

References related to abnormalities published in Invest. Ophthalmol. Vis. Sci.


PMIDJournalPublished DateAuthorTitle
18385062Invest. Ophthalmol. Vis. Sci.2008He Y et al.Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants.
18614807Invest. Ophthalmol. Vis. Sci.2008He Y et al.Mitochondrial defects and dysfunction in calcium regulation in glaucomatous trabecular meshwork cells.
22661471Invest. Ophthalmol. Vis. Sci.2012Daudt DR et al.Methylene blue protects primary rat retinal ganglion cells from cellular senescence.
24150756Invest. Ophthalmol. Vis. Sci.2013Han G et al.Mechanisms of neuroprotection by glucose in rat retinal cell cultures subjected to respiratory inhibition.
18235013Invest. Ophthalmol. Vis. Sci.2008Ghelli A et al.Protection against oxidant-induced apoptosis by exogenous glutathione in Leber hereditary optic neuropathy cybrids.