7-Ketocholesterol
7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
References related to locations published in Invest. Ophthalmol. Vis. Sci.
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 18936140 | Invest. Ophthalmol. Vis. Sci. | 2009 | Moreira EF et al. | 7-Ketocholesterol is present in lipid deposits in the primate retina: potential implication in the induction of VEGF and CNV formation. |
| 19834037 | Invest. Ophthalmol. Vis. Sci. | 2010 | Gramajo AL et al. | Mitochondrial DNA damage induced by 7-ketocholesterol in human retinal pigment epithelial cells in vitro. |
| 20554621 | Invest. Ophthalmol. Vis. Sci. | 2010 | Larrayoz IM et al. | 7-ketocholesterol-induced inflammation: involvement of multiple kinase signaling pathways via NFκB but independently of reactive oxygen species formation. |
| 17325185 | Invest. Ophthalmol. Vis. Sci. | 2007 | Neekhra A et al. | Caspase-8, -12, and -3 activation by 7-ketocholesterol in retinal neurosensory cells. |
| 17122150 | Invest. Ophthalmol. Vis. Sci. | 2006 | Luthra S et al. | Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells. |