Retinal
Retinal is a lipid of Prenol Lipids (PR) class. Retinal is associated with abnormalities such as Retinal Detachment, Uveitis, Endophthalmitis, Infection and LEBER CONGENITAL AMAUROSIS, TYPE II (disorder). The involved functions are known as Pigment, immunoreactivity, Infiltration, Energy Absorption and chromophore. Retinal often locates in Entire visual system, Autosome, Membrane, Basement membrane and Thoracic region (surface region of back). The associated genes with Retinal are isorhodopsin, RPE65 gene, RND1 gene, RPE gene and CASP8AP2 gene. The related lipids are Phosphatidylserines, Membrane Lipids, Fatty Acids, Liposomes and oxidized lipid. The related experimental models are Mouse Model, Knock-out and Genetically Engineered Mouse.
References related to abnormalities published in Invest. Ophthalmol. Vis. Sci.
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 11222515 | Invest. Ophthalmol. Vis. Sci. | 2001 | Tan E et al. | The relationship between opsin overexpression and photoreceptor degeneration. |
| 11687551 | Invest. Ophthalmol. Vis. Sci. | 2001 | Katz ML and Redmond TM | Effect of Rpe65 knockout on accumulation of lipofuscin fluorophores in the retinal pigment epithelium. |
| 12657577 | Invest. Ophthalmol. Vis. Sci. | 2003 | Qtaishat NM et al. | Acute radiolabeling of retinoids in eye tissues of normal and rpe65-deficient mice. |
| 12506090 | Invest. Ophthalmol. Vis. Sci. | 2003 | Rohrer B et al. | Correlation of regenerable opsin with rod ERG signal in Rpe65-/- mice during development and aging. |
| 14638739 | Invest. Ophthalmol. Vis. Sci. | 2003 | Rizzo JF et al. | Perceptual efficacy of electrical stimulation of human retina with a microelectrode array during short-term surgical trials. |
| 20805567 | Invest. Ophthalmol. Vis. Sci. | 2010 | Sparrow JR et al. | Interpretations of fundus autofluorescence from studies of the bisretinoids of the retina. |
| 21228385 | Invest. Ophthalmol. Vis. Sci. | 2011 | Fan J et al. | Light prevents exogenous 11-cis retinal from maintaining cone photoreceptors in chromophore-deficient mice. |
| 19324864 | Invest. Ophthalmol. Vis. Sci. | 2009 | Vázquez-Chona FR et al. | Rlbp1 promoter drives robust Müller glial GFP expression in transgenic mice. |
| 19060264 | Invest. Ophthalmol. Vis. Sci. | 2009 | Berkowitz BA et al. | Quantitative mapping of ion channel regulation by visual cycle activity in rodent photoreceptors in vivo. |
| 19553623 | Invest. Ophthalmol. Vis. Sci. | 2009 | Maeda A et al. | Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina. |
| 19407011 | Invest. Ophthalmol. Vis. Sci. | 2009 | Kunchithapautham K et al. | Cone outer segment morphology and cone function in the Rpe65-/- Nrl-/- mouse retina are amenable to retinoid replacement. |
| 20574023 | Invest. Ophthalmol. Vis. Sci. | 2010 | Tang PH et al. | Effective and sustained delivery of hydrophobic retinoids to photoreceptors. |
| 22039245 | Invest. Ophthalmol. Vis. Sci. | 2011 | Yamamoto K et al. | A novel bisretinoid of retina is an adduct on glycerophosphoethanolamine. |
| 17251447 | Invest. Ophthalmol. Vis. Sci. | 2007 | Wenzel A et al. | RPE65 is essential for the function of cone photoreceptors in NRL-deficient mice. |
| 18172125 | Invest. Ophthalmol. Vis. Sci. | 2008 | Mactier H et al. | Ocular biometry in preterm infants: implications for estimation of retinal illuminance. |
| 18326740 | Invest. Ophthalmol. Vis. Sci. | 2008 | Feathers KL et al. | Nrl-knockout mice deficient in Rpe65 fail to synthesize 11-cis retinal and cone outer segments. |
| 18296659 | Invest. Ophthalmol. Vis. Sci. | 2008 | Fan J et al. | Rpe65-/- and Lrat-/- mice: comparable models of leber congenital amaurosis. |
| 15790918 | Invest. Ophthalmol. Vis. Sci. | 2005 | Znoiko SL et al. | Downregulation of cone-specific gene expression and degeneration of cone photoreceptors in the Rpe65-/- mouse at early ages. |
| 15037595 | Invest. Ophthalmol. Vis. Sci. | 2004 | Aleman TS et al. | Impairment of the transient pupillary light reflex in Rpe65(-/-) mice and humans with leber congenital amaurosis. |
| 17003450 | Invest. Ophthalmol. Vis. Sci. | 2006 | Maeda A et al. | Improvement in rod and cone function in mouse model of Fundus albipunctatus after pharmacologic treatment with 9-cis-retinal. |
| 16505036 | Invest. Ophthalmol. Vis. Sci. | 2006 | Ostojić J et al. | Neuroglobin and cytoglobin: oxygen-binding proteins in retinal neurons. |
| 16505056 | Invest. Ophthalmol. Vis. Sci. | 2006 | Chen Y et al. | RPE65 gene delivery restores isomerohydrolase activity and prevents early cone loss in Rpe65-/- mice. |
| 16186377 | Invest. Ophthalmol. Vis. Sci. | 2005 | Rohrer B et al. | Cone opsin mislocalization in Rpe65-/- mice: a defect that can be corrected by 11-cis retinal. |
| 17197514 | Invest. Ophthalmol. Vis. Sci. | 2007 | Kanan Y et al. | Light induces programmed cell death by activating multiple independent proteases in a cone photoreceptor cell line. |
| 21960553 | Invest. Ophthalmol. Vis. Sci. | 2011 | Ablonczy Z et al. | Human retinal pigment epithelium cells as functional models for the RPE in vivo. |
| 22918645 | Invest. Ophthalmol. Vis. Sci. | 2012 | Gao SQ et al. | A microparticle/hydrogel combination drug-delivery system for sustained release of retinoids. |
| 23249702 | Invest. Ophthalmol. Vis. Sci. | 2013 | Maeda T et al. | QLT091001, a 9-cis-retinal analog, is well-tolerated by retinas of mice with impaired visual cycles. |
| 18469196 | Invest. Ophthalmol. Vis. Sci. | 2008 | Liang L et al. | Reprogramming progeny cells of embryonic RPE to produce photoreceptors: development of advanced photoreceptor traits under the induction of neuroD. |