Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

References related to genes published in J. Antimicrob. Chemother.

PMID	Journal	Published Date	Author	Title
10473232	J. Antimicrob. Chemother.	1999	Butler T et al.	Treatment of typhoid fever with azithromycin versus chloramphenicol in a randomized multicentre trial in India.
11152432	J. Antimicrob. Chemother.	2001	Amsden GW and Gray CL	Serum and WBC pharmacokinetics of 1500 mg of azithromycin when given either as a single dose or over a 3 day period in healthy volunteers.
11679558	J. Antimicrob. Chemother.	2001	Contopoulos-Ioannidis DG et al.	Meta-analysis of randomized controlled trials on the comparative efficacy and safety of azithromycin against other antibiotics for lower respiratory tract infections.
12205072	J. Antimicrob. Chemother.	2002	Kopjar B	Azithromycin is effective in patients with chronic bronchitis.
12654747	J. Antimicrob. Chemother.	2003	Carryn S et al.	Activity of beta-lactams (ampicillin, meropenem), gentamicin, azithromycin and moxifloxacin against intracellular Listeria monocytogenes in a 24 h THP-1 human macrophage model.
12775677	J. Antimicrob. Chemother.	2003	Zhanel GG et al.	Pharmacodynamic activity of azithromycin against macrolide-susceptible and -resistant Streptococcus pneumoniae simulating clinically achievable free serum, epithelial lining fluid and middle ear fluid concentrations.
12461037	J. Antimicrob. Chemother.	2002	Chiu LM et al.	Pharmacokinetics of intravenous azithromycin and ceftriaxone when administered alone and concurrently to healthy volunteers.
10980164	J. Antimicrob. Chemother.	2000	Jonas D et al.	The effect of azithromycin on intracellular Legionella pneumophila in the Mono Mac 6 cell line at serum concentrations attainable in vivo.
10882684	J. Antimicrob. Chemother.	2000	Koch CC et al.	Apoptosis, oxidative metabolism and interleukin-8 production in human neutrophils exposed to azithromycin: effects of Streptococcus pneumoniae.
15163653	J. Antimicrob. Chemother.	2004	Wyrick PB and Knight ST	Pre-exposure of infected human endometrial epithelial cells to penicillin in vitro renders Chlamydia trachomatis refractory to azithromycin.
21081549	J. Antimicrob. Chemother.	2011	Roberts MC et al.	Characterization of macrolide resistance genes in Haemophilus influenzae isolated from children with cystic fibrosis.
18931390	J. Antimicrob. Chemother.	2009	Ishimoto H et al.	Different effects of telithromycin on MUC5AC production induced by human neutrophil peptide-1 or lipopolysaccharide in NCI-H292 cells compared with azithromycin and clarithromycin.
19468025	J. Antimicrob. Chemother.	2009	Chisholm SA et al.	Emergence of high-level azithromycin resistance in Neisseria gonorrhoeae in England and Wales.
18230686	J. Antimicrob. Chemother.	2008	Murphy BS et al.	Azithromycin alters macrophage phenotype.
16260445	J. Antimicrob. Chemother.	2005	Higa F et al.	In vitro activity of pazufloxacin, tosufloxacin and other quinolones against Legionella species.
16002421	J. Antimicrob. Chemother.	2005	Girard D et al.	Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.
18552343	J. Antimicrob. Chemother.	2008	Palmer HM et al.	Emergence and spread of azithromycin-resistant Neisseria gonorrhoeae in Scotland.
23248239	J. Antimicrob. Chemother.	2013	Cory TJ et al.	Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.