clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

References related to genes published in J. Antimicrob. Chemother.

PMID	Journal	Published Date	Author	Title
10223590	J. Antimicrob. Chemother.	1999	Sato K and Tomioka H	Antimicrobial activities of benzoxazinorifamycin (KRM-1648) and clarithromycin against Mycobacterium avium-intracellulare complex within murine peritoneal macrophages, human macrophage-like cells and human alveolar epithelial cells.
11679568	J. Antimicrob. Chemother.	2001	Lascols C et al.	Effect of pH on the susceptibility of Helicobacter pylori to the ketolide telithromycin (HMR 3647) and clarithromycin.
11909833	J. Antimicrob. Chemother.	2002	McNulty C et al.	Helicobacter pylori susceptibility testing by disc diffusion.
12003967	J. Antimicrob. Chemother.	2002	Kikuchi T et al.	Clarithromycin suppresses lipopolysaccharide-induced interleukin-8 production by human monocytes through AP-1 and NF-kappa B transcription factors.
12096020	J. Antimicrob. Chemother.	2002	Koga T et al.	Effect of plaunotol in combination with clarithromycin or amoxicillin on Helicobacter pylori in vitro and in vivo.
12407126	J. Antimicrob. Chemother.	2002	Mainz D et al.	Pharmacokinetics of lansoprazole, amoxicillin and clarithromycin after simultaneous and single administration.
12461005	J. Antimicrob. Chemother.	2002	Matysiak-Budnik T et al.	In vitro transfer of clarithromycin and amoxicillin across the epithelial barrier: effect of Helicobacter pylori.
10747833	J. Antimicrob. Chemother.	2000	Paton R et al.	Susceptibility testing of Haemophilus influenzae to clarithromycin.
11062193	J. Antimicrob. Chemother.	2000	Edlund C et al.	Pharmacokinetics and comparative effects of telithromycin (HMR 3647) and clarithromycin on the oropharyngeal and intestinal microflora.
10933651	J. Antimicrob. Chemother.	2000	Theron AJ et al.	Investigation of the anti-inflammatory and membrane-stabilizing potential of spiramycin in vitro.
11020260	J. Antimicrob. Chemother.	2000	Alarcón T et al.	Clarithromycin resistance stability in Helicobacter pylori: influence of the MIC and type of mutation in the 23S rRNA.
10702548	J. Antimicrob. Chemother.	2000	Ives TJ et al.	In vitro susceptibilities of Rickettsia and Bartonella spp. to 14-hydroxy-clarithromycin as determined by immunofluorescent antibody analysis of infected vero cell monolayers.
21393190	J. Antimicrob. Chemother.	2011	Inagaki T et al.	Evaluation of a rapid detection method of clarithromycin resistance genes in Mycobacterium avium complex isolates.
21406436	J. Antimicrob. Chemother.	2011	Cirioni O et al.	Effect of the combination of clarithromycin and amikacin on Pseudomonas aeruginosa biofilm in an animal model of ureteral stent infection.
20008044	J. Antimicrob. Chemother.	2010	De Francesco V et al.	Phenotypic and genotypic Helicobacter pylori clarithromycin resistance and therapeutic outcome: benefits and limits.
16284224	J. Antimicrob. Chemother.	2006	Posteraro P et al.	Rapid detection of clarithromycin resistance in Helicobacter pylori using a PCR-based denaturing HPLC assay.
17412724	J. Antimicrob. Chemother.	2007	Shinkai M et al.	Clarithromycin has an immunomodulatory effect on ERK-mediated inflammation induced by Pseudomonas aeruginosa flagellin.
17827146	J. Antimicrob. Chemother.	2007	Sasaki M et al.	Effect of plaunotol in combination with clarithromycin against clarithromycin-resistant Helicobacter pylori in vitro and in vivo.
16024590	J. Antimicrob. Chemother.	2005	Sun HK et al.	Efficacy of pulsatile amoxicillin and clarithromycin dosing alone and in combination in a murine pneumococcal pneumonia model.
22833642	J. Antimicrob. Chemother.	2012	Maurer FP et al.	Acquisition of clarithromycin resistance mutations in the 23S rRNA gene of Mycobacterium abscessus in the presence of inducible erm(41).