Lysophosphatidylcholine

Lysophosphatidylcholine is a lipid of Glycerophospholipids (GP) class. Lysophosphatidylcholine is associated with abnormalities such as Ischemia, Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Fatty Liver and Atherosclerosis. The involved functions are known as Inflammation, antagonists, Signal Transduction, Signal Pathways and Saturated. Lysophosphatidylcholine often locates in Body tissue, Head, integral to membrane, Membrane and Extracellular. The associated genes with Lysophosphatidylcholine are RHOA gene, Homologous Gene, GPR4 gene, GPR68 gene and TRPV2 gene. The related lipids are Nonesterified Fatty Acids, lysophosphatidylethanolamine, Lysophosphatidylcholines, Phosphatidylserines and 25-hydroxycholesterol. The related experimental models are Knock-out and Disease model.

References related to abnormalities published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
23897815	J. Biol. Chem.	2013	Jiang S et al.	Mitochondria and AMP-activated protein kinase-dependent mechanism of efferocytosis.
18801741	J. Biol. Chem.	2008	Sato H et al.	Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis.
12740385	J. Biol. Chem.	2003	Golodne DM et al.	Lysophosphatidylcholine acts as an anti-hemostatic molecule in the saliva of the blood-sucking bug Rhodnius prolixus.
12183451	J. Biol. Chem.	2002	van der Luit AH et al.	Alkyl-lysophospholipid accumulates in lipid rafts and induces apoptosis via raft-dependent endocytosis and inhibition of phosphatidylcholine synthesis.
11042169	J. Biol. Chem.	2001	Cieslik K et al.	Up-regulation of endothelial nitric-oxide synthase promoter by the phosphatidylinositol 3-kinase gamma /Janus kinase 2/MEK-1-dependent pathway.
10574932	J. Biol. Chem.	1999	Cieslik K et al.	Transcriptional regulation of endothelial nitric-oxide synthase by an interaction between casein kinase 2 and protein phosphatase 2A.
9614091	J. Biol. Chem.	1998	Cieslik K et al.	Transcriptional regulation of endothelial nitric-oxide synthase by lysophosphatidylcholine.
9506985	J. Biol. Chem.	1998	Wong JT et al.	Lysophosphatidylcholine stimulates the release of arachidonic acid in human endothelial cells.
7493959	J. Biol. Chem.	1995	Günther-Ausborn S et al.	Inhibition of influenza-induced membrane fusion by lysophosphatidylcholine.
7542654	J. Biol. Chem.	1995	Zembowicz A et al.	Transcriptional induction of endothelial nitric oxide synthase type III by lysophosphatidylcholine.