Sphinganine

Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.

References related to abnormalities published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
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9188480	J. Biol. Chem.	1997	van Echten-Deckert G et al.	cis-4-Methylsphingosine decreases sphingolipid biosynthesis by specifically interfering with serine palmitoyltransferase activity in primary cultured neurons.
9933590	J. Biol. Chem.	1999	Alemany R et al.	Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase.
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17322298	J. Biol. Chem.	2007	Cowart LA and Hannun YA	Selective substrate supply in the regulation of yeast de novo sphingolipid synthesis.
22277656	J. Biol. Chem.	2012	Montefusco DJ et al.	Sphingoid bases and the serine catabolic enzyme CHA1 define a novel feedforward/feedback mechanism in the response to serine availability.
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20110363	J. Biol. Chem.	2010	Pewzner-Jung Y et al.	A critical role for ceramide synthase 2 in liver homeostasis: I. alterations in lipid metabolic pathways.