Laurylsphingosine

Laurylsphingosine is a lipid of Sphingolipids (SP) class. Laurylsphingosine is associated with abnormalities such as BOSLEY-SALIH-ALORAINY SYNDROME, Obesity and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as ceramide biosynthetic process, Anabolism, Signal, Signal Transduction and Transcriptional Activation. Laurylsphingosine often locates in Protoplasm, Plasma membrane, Epidermis, lamellar body and Stratum corneum. The associated genes with Laurylsphingosine are CFB gene. The related lipids are Nonesterified Fatty Acids, Fatty Acids, Sphingolipids, Palmitates and Stearates.

References related to abnormalities published in J. Biol. Chem.


PMIDJournalPublished DateAuthorTitle
9545298J. Biol. Chem.1998Watanabe R et al.Up-regulation of glucosylceramide synthase expression and activity during human keratinocyte differentiation.
15774472J. Biol. Chem.2005Chavez JA et al.Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling.